Regulation of lipoprotein lipase

Garfinkel, Arlene S.; Nilsson‐Ehle, Peter; Schotz, Michael C.

doi:10.1016/0005-2760(76)90194-6

Cited by 159 publications

(69 citation statements)

References 19 publications

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“…18 In fact, we found that the high-sucrose diet increased plasma insulin in both VMH-lesioned and sham-operated rats, and these rats showed increased TGSR and postheparin plasma LPL. The high-fat diet was associated with increased plasma insulin in both VMH-lesioned and sham-operated rats.…”

Section: Discussionmentioning

confidence: 74%

Different origin of hypertriglyceridemia induced by a high-fat and a high-sucrose diet in ventromedial hypothalamic-lesioned obese and normal rats

Kageyama

Kashiba

et al. 2001

Int J Obes

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OBJECTIVE: To clarify the mechanism by which plasma triacylglycerol is affected by a high fat or a sucrose diet. DESIGN: Two sets of six groups each having six rats were prepared Ð (1) ventromedial hypothalamic (VMH)-lesioned rats fed a standard diet; (2) sham VMH-lesioned rats fed a standard diet; (3) VMH-lesioned rats fed a high-fat diet; (4) sham VMH-lesioned rats fed a high-fat diet; (5) VMH-lesioned rats fed a high-sucrose diet; and (6) sham VMH-lesioned rats fed a high-sucrose diet. After VMH lesions and sham operations, the rats were provided standard, high-fat and high sucrose diets for 2 weeks. Two weeks later, blood samples were collected after overnight fast to determine plasma triacylglycerol (TAG), hepatic triacylglycerol secretion rate (TGSR), fractional catabolic rate (FCR) of triacylglycerol and postheparin plasma lipoprotein lipase (LPL), plasma glucose, insulin and leptin. RESULTS: Values of TAG, TGSR, FCR and LPL in VMH-lesioned obese rats were all greater than those in sham-operated rats, regardless of the diet fed. In sham-operated rats, high-fat diet fed rats showed higher TAG with similar TGSR, higher LPL and lower FCR than those of standard diet fed rats. High-sucrose diet fed rats showed signi®cantly higher TAG with higher TGSR, higher LPL and lower FCR than those of standard diet fed rats. Moreover, high-sucrose diet fed rats showed higher TAG with higher TGSR, lower LPL and higher FCR than those of high-fat diet fed rats. In VMH-lesioned rats, high-fat diet fed rats showed higher TAG with similar TGSR, higher LPL and lower FCR than those of standard diet fed rats. High-sucrose diet fed rats showed markedly higher TAG with notably higher TGSR, higher LPL and lower FCR than those of standard diet fed rats. High-sucrose diet fed rats showed still higher TAG with markedly higher TGSR, similar LPL and higher FCR than those of high-fat diet fed rats. CONCLUSIONS: The mechanism by which TAG metabolism is affected by a high-fat or a high-sucrose diet differed; a high-fat diet increased plasma TAG level by lowering removal of TAG without increase in hepatic TAG secretion in sham-operated (normal) rats. A high-sucrose diet, in contrast, induced much higher plasma TAG levels by both increased hepatic TAG secretion and decreased removal of TAG. The effects of a high-fat or a high-sucrose diet were similar but exaggerated in VMH lesioned animals.

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Section: Discussionmentioning

confidence: 74%

Different origin of hypertriglyceridemia induced by a high-fat and a high-sucrose diet in ventromedial hypothalamic-lesioned obese and normal rats

Kageyama

Kashiba

et al. 2001

Int J Obes

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“…Tanaka et (1971) reported a reduction in insulin secretion after intravenous injection of propranolol. As well known, insulin is required for the synthesis of LPL and for maintaining normal LPL activity and adequate TG transport through its ability to channel FFA towards different tissues according to the needs of the tissues (Garfinkel et al 1976 ;Fielding and Havel 1977). Thus a reduced insulin secretion may suppress LPL activity in the adipose tissue, leading to hyperlipidemia during prolonged f3-blocker treatment.…”

Section: Lipid and Lipoprotein Concentrations In Plasmamentioning

confidence: 99%

Effect of pindolol, a .BETA.-adrenoceptor blocking agent, on lipid metabolism.

Maebashi

Yoshinaga

Suzuki

1984

Tohoku J. Exp. Med.

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“…Oil emulsion (20%, v/v) was prepared by sonifying the fatty acid free olive oil in a5% gum arabic solution at 50 watts/10 ml with a Branson sonifier. (Girfunkel, et al, 1976 …”

Section: Chemicalsmentioning

confidence: 99%