Regulation of leg size and shape by the Dachsous/Fat signalling pathway during regeneration

Bando, Toshikazu; Mito, Taro; Maeda, Yuko; Nakamura, Taro; Ito, F.; Watanabe, Takahito; Ohuchi, Hideyo; Noji, Sumihare

doi:10.1242/dev.035204

Cited by 79 publications

(149 citation statements)

References 50 publications

(90 reference statements)

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“…5A) (Bando et al, 2009). Gb'ds is highly expressed in the distal region of each leg segment primordium (Fig.…”

Section: Relationship Between Morphogen Gradients and The Ds-ft Signamentioning

confidence: 94%

“…Expression of Gb'fj was observed in the proximal region of each segment. Gb'ft and Gb'ds are expressed during regeneration (Bando et al, 2009). An EGF ligand is expressed at the tip of the limb bud (our unpublished data).…”

Section: Involvement Of the Ds-ft Signaling System In Planar Cell Polmentioning

confidence: 99%

“…5A). Gb'fj is highly expressed in the proximal region of each segment primordium (Bando et al, 2009). Putative linear distributions of their proteins in a leg segment are schematically illustrated in Figure 5B.…”

Section: Relationship Between Morphogen Gradients and The Ds-ft Signamentioning

confidence: 99%

“…Recently, the Ds-Ft and Wts-Hpo signaling pathways were demonstrated to be actually involved in intercalary leg regeneration as well as normal regeneration after leg amputation using the cricket G. bimaculatus (Bando et al, 2009). The greatest advantage of the cricket system is that regeneration-dependent RNAi (rdRNAi) can be used for loss-of-function analyses.…”

Section: Roles Of the Ds-ft And Wts-hpo Signaling Pathways During Legmentioning

confidence: 99%

“…Cloned Gryllus homologs are indicated by solid lines, with factors predicted from Drosophila data indicated by dotted lines. Yellow indicates factors whose RNAi phenotypes were observed during Gryllus leg regeneration (Bando et al, 2009). D: Gene names and symbols are as follows; 14-3-3e (14-3-3e), 14-3-3j (14-3-3j), Approximated (App), Cyclin B (CycB), Cyclin E (CycE), Dachs (D), Discs overgrown (Dco), Drosophila inhibitor of apoptosis 1 (Diap1), Dachsous (Ds), Expanded (Ex), Fat (Ft), Four-jointed (Fj), Grunge (Gug), Hippo (Hpo), Kibra (Kibra), Lowfat (Lft), Mob as tumor suppressor (Mats), Merlin (Mer), Ras association family (Rassf), Salvador (Sav), Scalopped (Sd), Serrate (Ser), Warts (Wts), Yorkie (Yki) (Varelas et al;Bando et al, 2009;Grusche et al, 2010;Kim et al 2010;Pan, 2010;Zhao et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Bando

Mito

Nakamura

et al. 2011

Developmental Dynamics

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How limb size and shape is regulated is a long-standing question in developmental and regeneration biology. Recently, the protocadherin Dachsous-Fat (Ds-Ft) signaling pathway has been found to be essential for wing development of the fly and leg regeneration of the cricket. The Ds-Ft signaling pathway is linked to the Warts-Hippo (Wts-Hpo) signaling pathway, leading to cell proliferation. Several lines of evidence have suggested that the Wts-Hpo signaling pathway is involved in the control of organ size, and that this pathway is regulated by Ds-Ft and Merlin-Expanded, which are linked to morphogens such as decapentaplegic/bone morphogenic protein, Wingless/Wnt, and epidermal growth factor. Here we review recent progress in elucidating mechanisms controlling leg size and shape in insects and vertebrates, focusing on the Ds-Ft signaling pathway. We also introduce a working model, Ds-Ft steepness model, to explain how steepness of the Ds-Ft gradient controls leg size along the proximodistal axis. Developmental Dynamics 240:1028-1041,

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“…5A) (Bando et al, 2009). Gb'ds is highly expressed in the distal region of each leg segment primordium (Fig.…”

Section: Relationship Between Morphogen Gradients and The Ds-ft Signamentioning

confidence: 94%

Section: Involvement Of the Ds-ft Signaling System In Planar Cell Polmentioning

confidence: 99%

Section: Relationship Between Morphogen Gradients and The Ds-ft Signamentioning

confidence: 99%

Section: Roles Of the Ds-ft And Wts-hpo Signaling Pathways During Legmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Bando

Mito

Nakamura

et al. 2011

Developmental Dynamics

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Regeneration in Crustaceans and Insects

Khan

Schuster

Smith-Bolton

2016

Encyclopedia of Life Sciences

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Many animal species have the capability to regenerate lost body parts. How regeneration takes place and why animals have varying potentials for regeneration remain active questions for biologists. The field of regenerative biology has witnessed unprecedented advances in the last several years owing to the availability of molecular and genomics tools and the establishment of many animal models. Regeneration research in arthropods has a long history, with extensive insights achieved from using model organisms from the taxa Crustacea and Insecta. Studies in animals ranging from fiddler crabs to crickets have revealed much about the different stages of regeneration, such as wound healing, blastema formation, growth, proliferation and patterning, as well as how hormonal control and systemic signalling impact regenerative capacity. The molecular and genetic insights achieved from studying these simpler model organisms have the potential to impact the field of regenerative biology by identifying conserved mechanisms of regeneration. Key Concepts Regeneration studies use the fiddler crab, crayfish, sand hopper, red flour beetle, fruit fly, cockroach, cricket and silverfish. For amputated limbs, wounds heal by a combination of rapid closure of the wound with a scab or autotomy membrane, and migration of cells into the wound. Imaginal disc wound closure involves cytoskeletal‐driven cell shape changes and zippering together of the epithelium, without cell migration. A regeneration blastema, or zone of proliferating cells, forms after both external limb amputation and imaginal disc damage. Growth of the blastema requires similar signals in multiple model organisms, including growth factor signalling in response to FGFs and EGFR activity, Wg/WNT signalling and Hippo signalling. Many developmental patterning genes are also required for patterning during regeneration. However, knockdown of these patterning genes revealed additional roles in regeneration beyond those observed during normal development. Some plasticity in cell fate enables replacement of lost cell types. Signals at the wound can alter pattern and cell fate, generating ectopic eye spots in butterflies and requiring the activity of a protective factor that stabilises cell fate gene expression during regeneration in fruit flies. Hormonal signalling, which controls moulting and metamorphosis, limits regenerative capacity. In some model organisms, tissue damage can influence hormone production and the timing of moults and metamorphosis.

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Imaginal discs: Renaissance of a model for regenerative biology

et al. 2010

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Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration.

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Regulation of leg size and shape by the Dachsous/Fat signalling pathway during regeneration

Cited by 79 publications

References 50 publications

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Regulation of leg size and shape: Involvement of the Dachsous‐fat signaling pathway

Regeneration in Crustaceans and Insects

Imaginal discs: Renaissance of a model for regenerative biology

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