Regulation of keratinocyte growth factor and scatter factor in cyclosporin‐induced gingival overgrowth

Abstract

These results suggest that KGF and SF may have an important role in cyclosporin-induced gingival overgrowth.

Cyclosporin‐Induced Downregulation of the Expression of E‐Cadherin During Proliferation of Edentulous Gingival Epithelium in Rats

“…However, studies on the effects of CsA on gingival epithelial cells are limited 9‐11 . Although CsA stimulates the production of keratinocyte growth factor, 12,13 which may cause epithelial proliferation in overgrown gingiva, exactly how the drug elicits epithelial hyperplasia in the gingiva is still under investigation.…”

Regulation of epithelial cell growth factor receptor protein and gene expression using a rat periodontitis model

“…As with KGF‐1, hepatocyte growth factor is also a paracrine‐mediating growth factor (7). HGF is expressed by a variety of oral tissue fibroblasts, and HGFR (c‐Met) is expressed primarily by epithelial cells (7,9–13). In this study, HGFR, when compared with KGFR, was expressed at a higher level in healthy individuals, but the relative increase with disease was significantly less (×25 vs. ×10).…”

“…Keratinocyte growth factor-1 (KGF-1) and hepatocyte growth factor (HGF) are principally expressed by connective tissue cells and classically stimulate epithelial cells through their relatively specific FGFR2-iiib (KGFR) and c-Met (HGFR) receptors, respectively (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Both growth factors are up-regulated in chronic inflammatory conditions (16)(17)(18)(19)(20)(21).…”

Involvement of apoptotic signals in cyclosporin A-induced proliferation of human gingival fibroblast

“…Recent previous reports have suggested that various growth factors may involve in cell proliferation promoted by CsA in human gingival fibroblast [12][13][14] . In addition, there is another possibility that antiapoptotic signals and its regulating molecules may be involved in enhanced proliferation by CsA in human gingival fibroblast since cell survival rate depends on balance between proliferation and cell death.…”