2024
DOI: 10.1002/cbin.12144
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Regulation of iron metabolism in HEC‐1A endometrium cells by macrophage‐derived factors and fractalkine

Edina Pandur,
Ramóna Pap,
Gergely Jánosa
et al.

Abstract: Macrophages in the endometrium promote receptivity and implantation by secreting proinflammatory cytokines and other factors like fractalkine (FKN). Macrophages are closely linked to regulating iron homeostasis and can modulate iron availability in the tissue microenvironment. It has been revealed that the iron metabolism of the mother is crucial in fertility. Iron metabolism is strictly controlled by hepcidin, the principal iron regulatory protein. The inflammatory cytokines can modulate hepcidin synthesis an… Show more

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