Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds

Basson, Abigail R.; Ahmed, Saleh Uddin Mansur; Almutairi, Rawan; Seo, Brian; Cominelli, Fabio

doi:10.3390/foods10040774

Cited by 40 publications

(28 citation statements)

References 258 publications

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“…With extensive recent developments in immunology, the concept of innate immunity and its relationship with diseases have created major interest in the scientific community. Inflammatory reactions inevitably appear in response to all stimuli in daily life, but they differ in severity [131][132][133]. When our body is healthy or when the infection is weak, it can control the inflammatory response and recover to normal, but when the ability to control the inflammatory response is weakened, the damage caused by inflammation can be more severe, leading to disease [133].…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

“…Soybeans contain a diverse array of health functional substances, the most representative of which are isoflavones. Soy isoflavones inhibit cancer cell growth by suppressing the expression of tyrosine kinase which has positive role in cancer cell growth, physiology, and division, while inducing apoptosis and controlling cell cycle [132]. In addition, soy isoflavones exhibit anticancer activity by inhibiting vasculogenesis which promotes cancer cell growth and metastasis as well as the migration to and activation in the nucleus of the transcription factor NF-κB (Figure 9) [147].…”

Section: Anticarcinogenic Activity Through Gene Regulationmentioning

confidence: 99%

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Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

2021

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Soybeans are rich in proteins and lipids and have become a staple part of the human diet. Besides their nutritional excellence, they have also been shown to contain various functional components, including isoflavones, and have consequently received increasing attention as a functional food item. Isoflavones are structurally similar to 17-β-estradiol and bind to estrogen receptors (ERα and ERβ). The estrogenic activity of isoflavones ranges from a hundredth to a thousandth of that of estrogen itself. Isoflavones play a role in regulating the effects of estrogen in the human body, depending on the situation. Thus, when estrogen is insufficient, isoflavones perform the functions of estrogen, and when estrogen is excessive, isoflavones block the estrogen receptors to which estrogen binds, thus acting as an estrogen antagonist. In particular, estrogen antagonistic activity is important in the breast, endometrium, and prostate, and such antagonistic activity suppresses cancer occurrence. Genistein, an isoflavone, has cancer-suppressing effects on estrogen receptor-positive (ER+) cancers, including breast cancer. It suppresses the function of enzymes such as tyrosine protein kinase, mitogen-activated kinase, and DNA polymerase II, thus inhibiting cell proliferation and inducing apoptosis. Genistein is the most biologically active and potent isoflavone candidate for cancer prevention. Furthermore, among the various physiological functions of isoflavones, they are best known for their antioxidant activities. S-Equol, a metabolite of genistein and daidzein, has strong antioxidative effects; however, the ability to metabolize daidzein into S-equol varies based on racial and individual differences. The antioxidant activity of isoflavones may be effective in preventing dementia by inhibiting the phosphorylation of Alzheimer’s-related tau proteins. Genistein also reduces allergic responses by limiting the expression of mast cell IgE receptors, which are involved in allergic responses. In addition, they have been known to prevent and treat various diseases, including cardiovascular diseases, metabolic syndromes, osteoporosis, diabetes, brain-related diseases, high blood pressure, hyperlipidemia, obesity, and inflammation. Further, it also has positive effects on menstrual irregularity in non-menopausal women and relieving menopausal symptoms in middle-aged women. Recently, soybean consumption has shown steep increasing trend in Western countries where the intake was previously only 1/20–1/50 of that in Asian countries. In this review, I have dealt with the latest research trends that have shown substantial interest in the biological efficacy of isoflavones in humans and plants, and their related mechanisms.

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Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Section: Anticarcinogenic Activity Through Gene Regulationmentioning

confidence: 99%

Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

2021

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“…Among the natural materials, soybeans have drawn substantial attention since they have been reported to contain various bioactive compounds, including tocopherols, soyasaponins, and isoflavones [ 18 , 19 ]. These functional substances not only improve metabolic and cardiovascular functions but also help to prevent obesity [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Bacillus Subtilis-Fermented White Sword Bean Extract on Adipogenesis and Lipolysis of 3T3-L1 Adipocytes

Choi

Kim

Lee

et al. 2021

Foods

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To investigate the adipogenesis and lipolysis effects of the Bacillus subtilis-fermented white sword bean extract (FWSBE) on 3T3-L1 adipocytes, we treated 3T3-L1 preadipocytes before and after differentiation with FWSBE and measured triglyceride, free glycerol, mRNA, and protein levels. First, FWSBE reduced the cell viability of 3T3-L1 pre-adipocytes under 1000 µg/mL conditions. Triglyceride accumulation in 3T3-L1 pre-adipocytes was suppressed, and free glycerol content in mature 3T3-L1 adipocytes was increased in the FWSBE treatment groups, indicating that FWSBE has anti-obesity effects. Further, FWSBE suppressed adipogenesis in 3T3-L1 pre-adipocytes by lowering the protein levels of C/EBPα, PPARγ, and FAS and increasing the level of pACC and pAMPK. Additionally, FWSBE promoted lipolysis in mature 3T3-L1 adipocytes by increasing the transcription levels of Ppara, Acox, and Lcad and the protein levels of pHSL and ATGL. Thus, we suggest that FWSBE can be a potential dietary supplement because of its anti-obesity properties.

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“…Another study revealed that the intake of dietary daidzein significantly increased the population of two equol-generating bacteria, Slackia isoflavoniconvertens and Asaccharobacter celatus [ 116 ]. Moreover, numerous studies conducted in humans and rodents showed that consumption of soy or soy food products affects intestinal ecology [ 114 , 117 , 118 , 119 , 120 ]. It was also stated that the total amount and/or relative percentage of the particular microbial ecosystem in the intestine might be altered by genistein in food or supplemental forms [ 121 ].…”

Section: Effect Of Different Phytochemical Compounds On the Modulatio...mentioning

confidence: 99%

The Impact of Plant Phytochemicals on the Gut Microbiota of Humans for a Balanced Life

Santhiravel

Bekhit

Mendis

et al. 2022

IJMS

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The gastrointestinal tract of humans is a complex microbial ecosystem known as gut microbiota. The microbiota is involved in several critical physiological processes such as digestion, absorption, and related physiological functions and plays a crucial role in determining the host’s health. The habitual consumption of specific dietary components can impact beyond their nutritional benefits, altering gut microbiota diversity and function and could manipulate health. Phytochemicals are non-nutrient biologically active plant components that can modify the composition of gut microflora through selective stimulation of proliferation or inhibition of certain microbial communities in the intestine. Plants secrete these components, and they accumulate in the cell wall and cell sap compartments (body) for their development and survival. These compounds have low bioavailability and long time-retention in the intestine due to their poor absorption, resulting in beneficial impacts on gut microbiota population. Feeding diets containing phytochemicals to humans and animals may offer a path to improve the gut microbiome resulting in improved performance and/or health and wellbeing. This review discusses the effects of phytochemicals on the modulation of the gut microbiota environment and the resultant benefits to humans; however, the effect of phytochemicals on the gut microbiota of animals is also covered, in brief.

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Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds

Cited by 40 publications

References 258 publications

Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

Effects of Bacillus Subtilis-Fermented White Sword Bean Extract on Adipogenesis and Lipolysis of 3T3-L1 Adipocytes

The Impact of Plant Phytochemicals on the Gut Microbiota of Humans for a Balanced Life

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