Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

Kosodo, Yoichi; Suetsugu, Taeko; Suda, Masumi; Mimori-Kiyosue, Yuko; Toida, Kazunori; Baba, Shoji A.; Kimura, Asako; Matsuzaki, Fumio

doi:10.1038/emboj.2011.81

Cited by 146 publications

(221 citation statements)

References 54 publications

(96 reference statements)

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“…It has been speculated that this may be a way of increasing the density of precursor cells while maintaining adherens junctions during mitosis (Frade 2002). In support of this view, it has been observed that migration towards the basal side of the VZ occurs in a passive manner due to migration of nuclei at the G2/M phase towards the apical side (Kosodo et al 2011). An additional option is that this movement allows differential exposure to environmental cues that differ in the apical (mitotic) versus the basal (neurogenic) domains.…”

Section: Interkinetic Nuclear Movementssupporting

confidence: 51%

“…The microtubule-associated protein Tpx2 may be involved in microtubule assembly in a cell cycle-specific manner. By redistribution in a cell cycle-dependent manner and an effect on microtubule organization, Tpx2 couples cell cycle and interkinetic nuclear movement (Kosodo et al 2011). Tpx2 begins to be expressed in S phase and accumulates in the nucleus.…”

Section: Molecular Motors and The Cytoskeletonmentioning

confidence: 99%

“…Upon entry into G2 phase, Tpx2 redistributes into the apical process and promotes nuclear migration. Cell cycle progression from G1 to S phase is a prerequisite for basal-to-apical nuclear migration, and Tpx2 is involved in regulating this motility; knockdown of Tpx2 perturbed basal-to-apical nuclear migration (Kosodo et al 2011). In addition to microtubules, microtubule dynamics may be affected by centrosomal-associated proteins, which may impact microtubules emanating from the centrosome and through this activity regulate interkinetic nuclear movement.…”

Section: Molecular Motors and The Cytoskeletonmentioning

confidence: 99%

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Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex

2011

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The nuclei of neuroepithelial cells move along the apicobasal axis in synchronization with their cell cycle status. This motility is known as interkinetic nuclear movement. We discuss here the importance of cytoskeleton organization, the centrosome, molecular motors, cell polarity proteins, and their regulators in controlling and maintaining this typical behavior. Furthermore, due to the tight linkage between cell proliferation, cell cycle, and nuclear motility, we speculate that interkinetic nuclear movement is likely to be affected in the pathophysiology of microcephaly, where the brain size is markedly reduced.

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Section: Interkinetic Nuclear Movementssupporting

confidence: 51%

Section: Molecular Motors and The Cytoskeletonmentioning

confidence: 99%

Section: Molecular Motors and The Cytoskeletonmentioning

confidence: 99%

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Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex

2011

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“…For example, many basal nuclear migrations during G1/S phase are passive, cell non-autonomous movements, during which G1/S nuclei are forced basally when G2 nuclei of neighboring cells actively migrate apically and, therefore, push G1/S nuclei out of the apical regions (Fig. 3A) (Kosodo et al, 2011). LINC-independent mechanisms that underlie apical movements during G2 are better understood.…”

Section: Nuclear Migration In Developing Epitheliamentioning

confidence: 99%

Nuclear migration events throughout development

Bone

Starr

2016

Journal of Cell Science

102

109

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Moving the nucleus to a specific position within the cell is an important event during many cell and developmental processes. Several different molecular mechanisms exist to position nuclei in various cell types. In this Commentary, we review the recent progress made in elucidating mechanisms of nuclear migration in a variety of important developmental models. Genetic approaches to identify mutations that disrupt nuclear migration in yeast, filamentous fungi, Caenorhabditis elegans, Drosophila melanogaster and plants led to the identification of microtubule motors, as well as Sad1p, UNC-84 (SUN) domain and Klarsicht, ANC-1, Syne homology (KASH) domain proteins (LINC complex) that function to connect nuclei to the cytoskeleton. We focus on how these proteins and various mechanisms move nuclei during vertebrate development, including processes related to wound healing of fibroblasts, fertilization, developing myotubes and the developing central nervous system. We also describe how nuclear migration is involved in cells that migrate through constricted spaces. On the basis of these findings, it is becoming increasingly clear that defects in nuclear positioning are associated with human diseases, syndromes and disorders.

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“…The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM), which may have a role in regulating cell cycle and proliferation [Del Bene et al, 2008]. During INM, the plus end-directed motor dynein and the minus end-directed motor kinesin are required for apical and basal migration of the nucleus, respectively [Tsai et al, 2010;Kosodo et al, 2011].…”

Section: Epithelial Cell Polarizationmentioning

confidence: 99%

Shaping microtubules into diverse patterns: Molecular connections for setting up both ends

Mimori-Kiyosue¹

2011

Cytoskeleton

Self Cite

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Microtubules serve as rails for intracellular trafficking and their appropriate organization is critical for the generation of cell polarity, which is a foundation of cell differentiation, tissue morphogenesis, ontogenesis and the maintenance of homeostasis. The microtubule array is not just a static railway network; it undergoes repeated collapse and reassembly in diverse patterns during cell morphogenesis. In the last decade much progress has been made toward understanding the molecular mechanisms governing complex microtubule patterning. This review first revisits the basic principle of microtubule dynamics, and then provides an overview of how microtubules are arranged in highly shaped and functional patterns in cells changing their morphology by factors controlling the fate of microtubule ends. V C 2011 Wiley Periodicals, Inc.

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Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

Cited by 146 publications

References 54 publications

Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex

Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex

Nuclear migration events throughout development

Shaping microtubules into diverse patterns: Molecular connections for setting up both ends

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