1998
DOI: 10.1038/bjc.1998.351
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Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2

Abstract: Summary Transcriptional activator interferon regulatory factor (IRF)-1 and repressor IRF-2 are known to play a critical role in the regulation of interferon (IFN) responses and oncogenesis in fibroblasts. Although these two factors are expressed in many tissues, including the brain, the role of IRFs in the central nervous system (CNS) has not been elucidated. We analysed a medulloblastoma cell line, ONS-76, as a CNSderived model system and generated its derivatives, Rl and R2 cells, which constitutively expres… Show more

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Cited by 6 publications
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“…These splicing aberrations in the IRF‐1 gene account for the loss of IRF‐1 expression and may constitute another general mechanism of tumour suppressor gene inactivation. Genetic alterations in the IRF‐1 gene have also been reported in other human cancers (Nozawa et al , 1998; Park et al , 1998; Tada et al , 1998). Changes in the relative balance between IRF‐1 and IRF‐2 lead to dysregulation of cell growth and may play a role in the development of neoplasias.…”
mentioning
confidence: 83%
“…These splicing aberrations in the IRF‐1 gene account for the loss of IRF‐1 expression and may constitute another general mechanism of tumour suppressor gene inactivation. Genetic alterations in the IRF‐1 gene have also been reported in other human cancers (Nozawa et al , 1998; Park et al , 1998; Tada et al , 1998). Changes in the relative balance between IRF‐1 and IRF‐2 lead to dysregulation of cell growth and may play a role in the development of neoplasias.…”
mentioning
confidence: 83%