1999
DOI: 10.1007/bf02786469
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Regulation of integrin function by T cell activation

Abstract: Lymphocyte adhesiveness is dynamically regulated in response to conditions in the extracellular environment. One mechanism of regulation of integrin adhesion receptors involves a rapid, but transient, increase in integrin function upon T lymphocyte activation. These integrin activating signals can be initiated either via ligation of Ig superfamily members that are coupled to tyrosine kinase cascades, such as the CD3/T cell receptor, CD2, and CD28, or by G protein-coupled receptors for chemokines. Analysis of i… Show more

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Cited by 25 publications
(20 citation statements)
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“…The functionality of the cultured salivary acinar cells in vitro is confirmed by their secretion and organization of their own basement membrane including the critical component perlecan that can support further growth and differentiation by virtue of its ability to interact with cell adhesion molecules that can influence integrin-mediated events. 11,15 Uniquely, no non-human-derived material was needed for isolation or culture of the acinar cells.…”
Section: Discussionmentioning
confidence: 99%
“…The functionality of the cultured salivary acinar cells in vitro is confirmed by their secretion and organization of their own basement membrane including the critical component perlecan that can support further growth and differentiation by virtue of its ability to interact with cell adhesion molecules that can influence integrin-mediated events. 11,15 Uniquely, no non-human-derived material was needed for isolation or culture of the acinar cells.…”
Section: Discussionmentioning
confidence: 99%
“…For example, the absence of ADAP also profoundly affects TCR-stimulated, integrin-mediated adhesion (70,71). Integrin receptors provide costimulatory signals to naive T cells by stabilizing contacts between the TCR and immobilized anti-CD3 Ab and decreasing the threshold for activation (73)(74)(75). Because PTP␣ positively regulates integrin signaling in fibroblasts (8,9), it might play a role in Ag-mediated interactions between the TCR and T cell integrins as well.…”
Section: Studies Of Fynmentioning
confidence: 99%
“…Efficient TCR signaling following T cell activation requires conjugate formation with an APC (38). The hyporesponsive state of orally tolerized T cells may be due to inefficient conjugate formation.…”
Section: Orally Tolerized T Cells Can Form Stable Conjugates With Apcsmentioning
confidence: 99%