Regulation of insulin-like growth factor-I and thioredoxin expression by estradiol in the reproductive tract of the prepubertal female lamb

Sahlin, Lena; Meikle, A.; Tasende, C.; Lindberg, Monica; Masironi, Britt; Eriksson, Håkan

doi:10.1016/s0960-0760(01)00042-5

Cited by 9 publications

(15 citation statements)

References 35 publications

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“…This is the first report of expression of NGF in the oviduct of the Shiba goat. It has been reported that the oviduct can secrete many growth factors, such as EGF, TGF, IGF, and activin [23][24][25]. In human oviducts, vascular e n d o t h e l i a l g r o w t h f a c t o r ( V E G F ) m R N A e x p r e s s i o n w a s t h e h i g h e s t d u r i n g t h e periovulatory stage, and its expression in the ampullary and infundibular regions was higher than that in the isthmus.…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization of Nerve Growth Factor (NGF) and Its Receptors (TrkA and p75LNGFR) in the Reproductive Organs of Shiba Goats

Ren

Medan

Wang

et al. 2005

Journal of Reproduction and Development

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Abstract. The objective of this study was to determine the immunolocalization of NGF and its receptors (TrkA and p75LNGFR) in the reproductive tract of the Japanese Shiba goats. Five adult goats were used in this study and sections of ovaries, uteri and oviducts were immunostained by the avidin-biotin-peroxidase complex method (ABC). The results showed that NGF and its receptors (TrkA and p75LNGFR) were expressed in granulosa cells, theca cells, interstitial cells and lutein cells in ovaries. Immunoreactions for NGF, TrkA and p75LNGFR were also detectable in epithelial cells and muscle cells of the ampulla and isthmus of the oviduct, and in epithelial cells and uterine glands of the uterus. These results strongly suggest autocrine and paracrine regulation of reproductive function by NGF in the reproductive tract of female Shiba goats.

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Section: Discussionmentioning

confidence: 99%

Immunolocalization of Nerve Growth Factor (NGF) and Its Receptors (TrkA and p75LNGFR) in the Reproductive Organs of Shiba Goats

Ren

Medan

Wang

et al. 2005

Journal of Reproduction and Development

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“…It has been reported that the oviduct can secrete many growth factors, such as epidermal growth factor (EGF), transforming growth factor (TGF), insulin-like growth factor (IGF), and activin [10,19,20]. These findings indicate that there are likely to be autocrine and paracrine oviductal and embryonic growth factor interactions supporting early embryo development in the oviduct.…”

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confidence: 99%

Immunolocalization of NGF and Its Receptors trkA and p75 in the Oviducts of Golden Hamsters during the Estrous Cycle

et al. 2009

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Abstract:To investigate the physiological roles of nerve growth factor (NGF) in the oviduct of golden hamsters during the estrous cycle, the localization of NGF and its receptors, trkA and p75, were determined by immunohistochemistry. Positive staining of NGF, trkA, and p75 was present in epithelial cells and muscle cells of the infundibulum, ampulla, and isthmus in the oviduct. The intensities of the immunohistochemical signals for NGF, trkA, and p75 did not markedly change in any segment of the oviduct during the estrous cycle. These results suggest that NGF may play autocrine/paracrine roles in oviductal transport, fertilization, capacitation of spermatozoa and early embryonic development in the oviduct of golden hamsters.

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“…Tubal liquid is a complex mixture composed of plasma and secreting protein (Verhage et al, 1988;Willis et al, 1994). The oviduct secretes many growth factors, such as epidermal growth factor (EGF), transformation growth factor (TGF), insulin-like growth factor-1 (IGF-1), and activin (Sahlin et al, 2001), indicating that both autocrine and paracrine embryo growth factors are present in the oviduct. In the present study, immune reactions to NGF and its two receptors were detected in epithelial cells of infundibulum, magnum and isthmus.…”

Section: Expression Of Nerve Growth Factor (Ngf) and Its Receptors Trmentioning

confidence: 99%

Expression of Nerve Growth Factor (NGF) and Its Receptors TrkA and p75 in the Reproductive Organs of Laying Hens

Changwei

et al. 2016

Rev. Bras. Cienc. Avic.

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In order to investigate the expression levels of nerve growth factor (NGF) and its receptors (TrkA and p75) in prehierarchical follicles and oviducts of hens, five 130-day-old laying hens were examined by immunohistochemistry and RT-PCR analysis. NGF and its receptors were expressed in theca cells and granulosa cells of prehierarchical follicles, and they were also expressed in the epithelial cells of oviducts. The expression of the genes NGF, TrkA and p75 were significantly different in prehierarchical follicles (p<0.05 or p<0.01), and NGF and TrkA gene expression was significantly different in different parts of oviduct (p<0.05 or p<0.01). The expression of NGF and p75 mRNA levels was highest in large white follicle (LWF), as well as the expression of TrkA in small yellow follicle (SYF). In the oviduct, the expression of NGF was the highest in infundibulum, and lowest in isthmus. These results suggest that NGF may play an important role in the regulation of hen reproduction.

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Regulation of insulin-like growth factor-I and thioredoxin expression by estradiol in the reproductive tract of the prepubertal female lamb

Cited by 9 publications

References 35 publications

Immunolocalization of Nerve Growth Factor (NGF) and Its Receptors (TrkA and p75LNGFR) in the Reproductive Organs of Shiba Goats

Immunolocalization of Nerve Growth Factor (NGF) and Its Receptors (TrkA and p75LNGFR) in the Reproductive Organs of Shiba Goats

Immunolocalization of NGF and Its Receptors trkA and p75 in the Oviducts of Golden Hamsters during the Estrous Cycle

Expression of Nerve Growth Factor (NGF) and Its Receptors TrkA and p75 in the Reproductive Organs of Laying Hens

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