Regulation of insulin biosynthesis in vivo by glucose in the newborn rat

Gespach, Christian; Jarrousse, C.; Rosselin, G

doi:10.1016/0026-0495(79)90009-x

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Exposure to elevated plasma glucose levels in the offspring of dams receiving sucrose supplementation was accompanied by increased sensitivity of the biosynthetic process to glucose, irrespective of caffeine exposure. The observation that exposure to raised plasma glucose increases proinsulin synthesis is in agreement with recently reported observations of the effect of glucose administration in vivo on pancreatic function in neonatal rats [19]. The physiological relevance of the contrast in the effect of maternal caffeine ingestion on the process of insulin secretion compared with proinsulin biosynthesis by the neonatal pancreas is best appreciated when the neonatal glucose concentrations in vivo are considered.…”

Section: Discussionsupporting

confidence: 90%

The effect of maternal caffeine ingestion on pancreatic function in the neonatal rat

1982

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Summary. Pancreatic function was investigated in neonatal suckling offspring of caffeine-ingesting dams, with or without maternal sucrose supplementation, throughout pregnancy and lactation. In offspring of rats ingesting caffeine without sucrose supplementation, there was initial hyperinsulinaemia, followed by a progressive fall of plasma insulin to subnormal levels. This fall in plasma insulin coincided with depletion of pancreatic insulin stores. Both the fall in plasma insulin and depletion of pancreatic insulin stores were prevented by sucrose supplementation of caffeine-ingesting dams. Offspring of dams fed sucrose alone and control offspring also maintained pancreatic insulin stores and circulating insulin levels over the first 14 days of postnatal life. Pancreases from offspring of caffeine-exposed animals tested in vitro showed enhanced sensitivity of the insulin release process to glucose. This was reflected in the glucose concentration required to elicit half-maximal insulin release (2.4 ___ 0.2 mmol/1 for caffeine offspring, 2.3 + 0.2 mmol/1 for caffeine with sucrose, 3.8 _+ 0.3 mmol/1 for sucrose and 4.1 + 0.3 mmol/1 for control offspring, mean +_ SEM). In contrast, offspring of sucrose-supplemented (with or without caffeine) dams showed increased sensitivity of the proinsulin biosynthetic process to glucose, whereas offspring of dams ingesting caffeine alone showed no significant enhancement of the biosynthetic process compared with control offspring. Thus enhanced sensitivity of the insulin secretory process to glucose without a change in the sensitivity of the biosynthetic process in the offspring of the caffeine ingesting (nonsucrose supplemented) dams could explain the progressive depletion of pancreatic insulin stores and eventual hypoinsulinaemia seen in this group.

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Section: Discussionsupporting

confidence: 90%

The effect of maternal caffeine ingestion on pancreatic function in the neonatal rat

1982

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“…Other possible fac tors in the development and augmentation of the insulin secretory pattern include postna tal elevation of corticosteroids [2] or other hormones, postnatal alteration in circulating prostaglandins [22], changes in pancreatic au tonomic innervation [8], alteration in islet cell calcium uptake [25]. or differences in insulin biosynthesis [11].…”

Section: Discussionmentioning

confidence: 99%

Maturation of Early-Phase Insulin Release in the Neonatal Lamb

1981

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Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early-phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.

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Regulation of insulin biosynthesis in vivo by glucose in the newborn rat

Cited by 2 publications

References 29 publications

The effect of maternal caffeine ingestion on pancreatic function in the neonatal rat

The effect of maternal caffeine ingestion on pancreatic function in the neonatal rat

Maturation of Early-Phase Insulin Release in the Neonatal Lamb

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