Regulation of insulin and type 1 insulin‐like growth factor signaling and action by the <scp>G</scp>rb10/14 and <scp>SH</scp>2<scp>B</scp>1/<scp>B</scp>2 adaptor proteins

Desbuquois, Bernard; Carré, Nadège; Burnol, Anne-Françoise

doi:10.1111/febs.12080

Cited by 67 publications

(79 citation statements)

References 162 publications

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“…Grb10 inhibits insulin signaling by interacting with IR in response to insulin stimulation (14). Once bound, Grb10 inhibits the catalytic activity of IR in a noncompetitive manner in concert with Grb7 and Grb14 (25). Additionally, Grb10 has recently been described as a phosphorylation substrate of the mTORC1 complex (26).…”

Section: Grb10 Is a Negative Regulator Of Growthmentioning

confidence: 99%

“…Conflicting studies, however, have reported that Grb10 has a positive effect on insulin signaling (9,30). It has been proposed that these results are due to the overexpression of different Grb10 isoforms and/or the use of cell types that are not insulin-sensitive (25). Other pathways important for growth are similarly inhibited by Grb10.…”

Section: Grb10 Is a Negative Regulator Of Growthmentioning

confidence: 99%

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Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

Plasschaert

Bartolomei

2014

Proc. Natl. Acad. Sci. U.S.A.

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Growth-factor receptor bound protein 10 (Grb10) is a signal adapter protein encoded by an imprinted gene that has roles in growth control, cellular proliferation, and insulin signaling. Additionally, Grb10 is critical for the normal behavior of the adult mouse. These functions are paralleled by Grb10’s unique tissue-specific imprinted expression; the paternal copy of Grb10 is expressed in a subset of neurons whereas the maternal copy is expressed in most other adult tissues in the mouse. The mechanism that underlies this switch between maternal and paternal expression is still unclear, as is the role for paternally expressed Grb10 in neurons. Here, we review recent work and present complementary data that contribute to the understanding of Grb10 gene regulation and function, with specific emphasis on growth and neuronal development. Additionally, we show that in vitro differentiation of mouse embryonic stem cells into alpha motor neurons recapitulates the switch from maternal to paternal expression observed during neuronal development in vivo. We postulate that this switch in allele-specific expression is related to the functional role of Grb10 in motor neurons and other neuronal tissues.

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Section: Grb10 Is a Negative Regulator Of Growthmentioning

confidence: 99%

Section: Grb10 Is a Negative Regulator Of Growthmentioning

confidence: 99%

Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

Plasschaert

Bartolomei

2014

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition of IRS and Shc, various signaling adaptors, including growth factor receptor bound protein 10 (Grb10), adaptor protein with pleckstrin homology (PH), and Src homology 2 (SH2) domain adaptor protein with pleckstrin homology and Src homology 2 domain (APS) or SH2B2, directly bind to IR and provide docking sites for other binding partners (8). Ubiquitin ligases neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) and c-casitas B-lineage lymphoma (Cbl) are examples of such binding partners for Grb10 and APS, respectively (8).…”

mentioning

confidence: 99%

“…Ubiquitin ligases neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) and c-casitas B-lineage lymphoma (Cbl) are examples of such binding partners for Grb10 and APS, respectively (8). Overall, Grb10 negatively regulates insulin signal transduction through multiple mechanisms of action (37).…”

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confidence: 99%

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The neuropilin-like protein ESDN regulates insulin signaling and sensitivity

Jung

Nie

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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Insulin effects on cell metabolism, growth, and survival are mediated by its binding to, and activation of, insulin receptor. With increasing prevalence of insulin resistance and diabetes there is considerable interest in identifying novel regulators of insulin signal transduction. The transmembrane protein endothelial and smooth muscle cell-derived neuropilinlike protein (ESDN) is a novel regulator of vascular remodeling and angiogenesis. Here, we investigate a potential role of ESDN in insulin signaling, demonstrating that Esdn gene deletion promotes insulininduced vascular smooth muscle cell proliferation and migration. This is associated with enhanced protein kinase B and mitogen-activated protein kinase activation as well as insulin receptor phosphorylation. Likewise, insulin signaling in the liver, muscle, and adipose tissue is enhanced in Esdn Ϫ/Ϫ mice, and these animals exhibit improved insulin sensitivity and glucose homeostasis in vivo. The effect of ESDN on insulin signaling is traced back to its interaction with insulin receptor, which alters the receptor interaction with regulatory adaptor protein-E3 ubiquitin ligase pairs, adaptor protein with pleckstrin homology and Src homology 2 domain-c-Cbl and growth factor receptor bound protein 10-neuronal precursor cell-expressed developmentally downregulated 4. In conclusion, our findings establish ESDN as an inhibitor of insulin receptor signal transduction through a novel regulatory mechanism. Loss of ESDN potentiates insulin's metabolic and mitotic effects and provides insights into a novel therapeutic avenue.

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Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

Vassilakos

Barton

2018

Comprehensive Physiology

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The insulin‐like growth factor (IGF) pathway is essential for promoting growth and survival of virtually all tissues. It bears high homology to its related protein insulin, and as such, there is an interplay between these molecules with regard to their anabolic and metabolic functions. Skeletal muscle produces a significant proportion of IGF‐1, and is highly responsive to its actions, including increased muscle mass and improved regenerative capacity. In this overview, the regulation of IGF‐1 production, stability, and activity in skeletal muscle will be described. Second, the physiological significance of the forms of IGF‐1 produced will be discussed. Last, the interaction of IGF‐1 with other pathways will be addressed. © 2019 American Physiological Society. Compr Physiol 9:413‐438, 2019.

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Regulation of insulin and type 1 insulin‐like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins

Abstract: Keywords cell growth; cell metabolism; Grb7/10/14 adaptor proteins; insulin; insulin-like growth factor 1; insulin receptor; insulin signaling and action; insulin-like growth factor 1 receptor; SH2B adaptor proteins; tyrosine kinase activity

Cited by 67 publications

References 162 publications

Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

The neuropilin-like protein ESDN regulates insulin signaling and sensitivity

Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

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