Regulation of innate immunity in marine mussel Mytilus coruscus: MicroRNA Mc-novel_miR_196 targets McTLR-like1 molecule to inhibit inflammatory response and apoptosis

Wu, Yashu; Si, Xirui; Qiu, Longmei; Chen, Xinglu; Fu, Peipei; Buttino, Isabella; Guo, Baoying; Liao, Zhi; Qi, Pengzhi

doi:10.1016/j.fsi.2023.108868

Cited by 7 publications

(1 citation statement)

References 39 publications

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“…Unlike vertebrates, mollusks do not have acquired immunity and rely only on innate immunity to protect themselves from external stimuli [41,42]. Therefore, the activated immune response in invertebrates is particularly important when stimulated by environmental factors.…”

Section: Analysis Of Inflammatory and Immune Responsesmentioning

confidence: 99%

Investigating the Mechanism of Low-Salinity Environmental Adaptation in Sepia esculenta Larvae through Transcriptome Profiling

Wang,

Liu,

Wang

et al. 2023

Animals

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Sepia esculenta is an economically important mollusk distributed in the coastal waters of China. Juveniles are more susceptible to stimulation by the external environment than mature individuals. The ocean salinity fluctuates due to environmental changes. However, there is a lack of research on the salinity adaptations of S. esculenta. Therefore, in this study, we investigated the differential expression of genes in S. esculenta larvae after stimulation by low salinity. RNA samples were sequenced and 1039 differentially expressed genes (DEGs) were identified. Then, enrichment analysis was performed using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Finally, a protein–protein interaction network (PPI) was constructed, and the functions of key genes in S. esculenta larvae after low-salinity stimulation were explored. We suggest that low salinity leads to an excess proliferation of cells in S. esculenta larvae that, in turn, affects normal physiological activities. The results of this study can aid in the artificial incubation of S. esculenta and reduce the mortality of larvae.

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Section: Analysis Of Inflammatory and Immune Responsesmentioning

confidence: 99%