Regulation of innate immune signaling pathways by autophagy in dengue virus infection

Wan, Shu-Wen; Lee, Ying-Ray; Ho, Tzong Shiann; Chang, Chih‐Peng

doi:10.1002/iub.2554

Cited by 5 publications

(4 citation statements)

References 76 publications

(99 reference statements)

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“…However, several forms of selective autophagy have been identified which lead to the degradation of specific organelle, proteins, and pathogens in mammals 22 . The canonical function of autophagy, that is, the formation of double‐membrane autophagosomes that deliver cargo to endolysosomal compartments, may exert several different antiviral roles, including (1) the degradation of intracytoplasmic viral components 23 ; (2) the activation of innate immune signaling 24 ; (3) the activation of adaptive immunity by the presentation of endogenous viral antigens to major histocompatibility complex (MHC) class I and MHC class II molecules 25 ; (4) the regulation of innate immune activation by mitochondrial quality control 26 ; and (5) the promotion of cell survival 27 . Autophagy acts as a double‐edged sword in viral infections.…”

Section: The Critical Role Of Bag3 In Autophagy Induced By Bovine Pap...mentioning

confidence: 99%

Role of BAG3 in bovine Deltapapillomavirus‐mediated autophagy

Roperto

2021

J of Cellular Biochemistry

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Bovine Deltapapillomavirus genus (δPV), comprises four members that are highly pathogenic and are frequently associated with bladder tumors of adult cattle and water buffaloes. In particular, bovine δPV‐2 and δPV‐13 are commonly found in urinary bladder tumors in adult large ruminants reared fully or partially on hilly/mountain pasturelands rich in bracken fern (Pteridium spp.) as the urinary bladder of the herbivores is the specific target for bracken genotoxins such as ptaquiloside (PT). PT is a sesquiterpenoid responsible for alkylation of adenine of codon 61 of gene H‐Ras, which results in Glutamine 61 substitution that is essential for guanosine triphosphate (GTP) hydrolysis. Glutamine substitution at position 61 impairs the intrinsic GTPase activity. Therefore, active GTP‐bound conformations (Ras‐GTP) accumulate in cells, thereby causing abnormal cell proliferation and differentiation. The aim of the present study is to stress how bovine δPVs upregulate different forms of selective autophagy, of which BAG3 is a key player. BAG3 plays a central role in autophagy and acts as a multifunctional hub for an interaction network at the cytosolic and mitochondrial level. BAG3 is a functional partner of bovine δPV E5 oncoprotein and forms a complex with molecular chaperones Hsc70/Hsp70/Hsp8B and with cochaperone CHIP. BAG3 interacts with Synpo2. It is believed that this interaction has a crucial role for autophagosome (mitophagosome) formation. Furthermore, in urothelial cells infected by bovine δPVs, BAG3 interacts with parkin and some receptors such as BNIP3/FUNDC1, which suggests that BAG3 is involved in both parkin‐dependent and ‐independent mitophagy that appear upregulate in bladder carcinogenesis of cattle induced by bovine δPVs. Surprisingly, BAG3 interacts also with ERAS, a protein encoded by the ERas gene, a novel member of the RAS family. Unlike in humans, the ERas gene is a functional gene in the cells of adult cattle, and it appears to play a role in bovine BAG3‐mediated selective autophagy, including mitophagy observed in urothelial cells spontaneously infected with bovine papillomavirus.

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Section: The Critical Role Of Bag3 In Autophagy Induced By Bovine Pap...mentioning

confidence: 99%

Role of BAG3 in bovine Deltapapillomavirus‐mediated autophagy

Roperto

2021

J of Cellular Biochemistry

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“…Activation of FOXO3a can suppress pro-inflammatory cytokines and reduce inflammation, thereby preventing tissue damage and improving clinical outcomes. Moreover, FOXO3a has been shown to promote autophagy which helps in clearing viral infections by degrading and recycling viral components (Wan et al, 2022). Therefore, the identification of genes involved in the FOXO signaling pathway may provide a novel therapeutic approach for COVID-19 and HFRS by regulating immune responses, oxidative stress, and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Discovering common pathogenic processes between COVID-19 and HFRS by integrating RNA-seq differential expression analysis with machine learning

et al. 2023

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Zoonotic virus spillover in human hosts including outbreaks of Hantavirus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) imposes a serious impact on the quality of life of patients. Recent studies provide a shred of evidence that patients with Hantavirus-caused hemorrhagic fever with renal syndrome (HFRS) are at risk of contracting SARS-CoV-2. Both RNA viruses shared a higher degree of clinical features similarity including dry cough, high fever, shortness of breath, and certain reported cases with multiple organ failure. However, there is currently no validated treatment option to tackle this global concern. This study is attributed to the identification of common genes and perturbed pathways by combining differential expression analysis with bioinformatics and machine learning approaches. Initially, the transcriptomic data of hantavirus-infected peripheral blood mononuclear cells (PBMCs) and SARS-CoV-2 infected PBMCs were analyzed through differential gene expression analysis for identification of common differentially expressed genes (DEGs). The functional annotation by enrichment analysis of common genes demonstrated immune and inflammatory response biological processes enriched by DEGs. The protein–protein interaction (PPI) network of DEGs was then constructed and six genes named RAD51, ALDH1A1, UBA52, CUL3, GADD45B, and CDKN1A were identified as the commonly dysregulated hub genes among HFRS and COVID-19. Later, the classification performance of these hub genes were evaluated using Random Forest (RF), Poisson Linear Discriminant Analysis (PLDA), Voom-based Nearest Shrunken Centroids (voomNSC), and Support Vector Machine (SVM) classifiers which demonstrated accuracy >70%, suggesting the biomarker potential of the hub genes. To our knowledge, this is the first study that unveiled biological processes and pathways commonly dysregulated in HFRS and COVID-19, which could be in the next future used for the design of personalized treatment to prevent the linked attacks of COVID-19 and HFRS.

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“…Autophagy is an evolutionarily conserved cellular process induced by nutrient starvation or lack of growth factors that clears unnecessary intracellular organelles and proteins to the lysosome for degradation [41]. Therefore, autophagy is also important in protein homeostasis, sequestering and degrading long-life proteins, and invading microbes [41,[51][52][53]. Beside the classical degradative autophagy, a non-canonical function called secretory autophagy, which regulates unconventional secretory processes, is raising attention [54,55].…”

Section: Discussionmentioning

confidence: 99%

Piperlongumine Induces Cellular Apoptosis and Autophagy via the ROS/Akt Signaling Pathway in Human Follicular Thyroid Cancer Cells

Lin

Kuo

Zhang

et al. 2023

IJMS

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Thyroid cancer (TC) is the most common endocrine malignancy. Recently, the global incidence of TC has increased rapidly. Differentiated thyroid cancer includes papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which are the most common types of TC. Although PTCs and FTCs exert good prognoses and high survival rates, FTCs tend to be more aggressive than PTCs. There is an urgent need to improve patient outcomes by developing effective therapeutic agents for FTCs. Piperlongumine exerts anti-cancer effects in various human carcinomas, including human anaplastic TCs and PTCs. However, the anti-cancer effects of piperlongumine in FTCs and the underlying mechanisms are yet to be elucidated. Therefore, in the present study, we evaluated the effect of piperlongumine on cell proliferation, cell cycle, apoptosis, and autophagy in FTC cells with flowcytometry and Western blot. We observed that piperlongumine caused growth inhibition, cell cycle arrest, apoptosis induction, and autophagy elevation in FTC cells. Activities of reactive oxygen species and the downstream PI3K/Akt pathway were the underlying mechanisms involved in piperlongumine mediated anti-FTC effects. Advancements in our understanding of the effects of piperlongumine in FTC hold promise for the development of novel therapeutic strategies.

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Regulation of innate immune signaling pathways by autophagy in dengue virus infection

Cited by 5 publications

References 76 publications

Role of BAG3 in bovine Deltapapillomavirus‐mediated autophagy

Role of BAG3 in bovine Deltapapillomavirus‐mediated autophagy

Discovering common pathogenic processes between COVID-19 and HFRS by integrating RNA-seq differential expression analysis with machine learning

Piperlongumine Induces Cellular Apoptosis and Autophagy via the ROS/Akt Signaling Pathway in Human Follicular Thyroid Cancer Cells

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