Regulation of innate immune responses by rabies virus

Zhang, Haili; Huang, Jingbo; Song, Yumeng; Liu, Xingqi; Qian, Meichen; Huang, Pei; Li, Yuanyuan; Zhao, Ling; Wang, Hualei

doi:10.1002/ame2.12273

Cited by 9 publications

(7 citation statements)

References 196 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degradation and lysis of bacteria by lysozyme cause the release of pathogen‐associated molecular patterns (PAMPs), which subsequently activate the pattern recognition receptors (PRRs) in host cells (Wan et al, 2022). The interaction of PAMPs and PRRs is recognized as the cornerstone of innate immunity (Yu et al, 2022; Zhang et al, 2022). Both BPI and LBP play vital roles in the defense against bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

Comparative Toxicological Effects of Perfluorooctane Sulfonate and Its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms

Ge,

Wang,

Chen

et al. 2023

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Abstract:High levels of 6:2 chlorinated polyfluorinated ether sulfonate (F‐53B), which is a substitute for perfluorooctane sulfonate (PFOS), are detected in various environmental matrices, wildlife and humans. F‐53B has received increased attention due to its potential risk to ecosystems. However, its toxicity in the soil organisms remains unclear. In this study, a comparative investigation was conducted on the toxicities of F‐53B and PFOS to the earthworm Eisenia. fetida. F‐53B was significantly more acutely toxic to earthworms than PFOS with LC50s of 1.43 and 1.83 mmol/kg dry soil (~816 and 984 mg/kg dry soil), respectively. Although both F‐53B and PFOS, at 0.4 mmol/kg dry soil (= 228 and 215 mg/kg dry soil) caused oxidative stress in earthworms, as evidenced by increased superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities as well as malondialdehyde (MDA) level, the stress caused by F‐53B was higher than that by PFOS. In the transcriptomic and metabolomic studies, negative effects of PFOS and F‐53B were observed on several metabolic processes in earthworms, including protein digestion and amino acid absorption, lipid metabolism, and the immune response. Compared to PFOS, F‐53B exhibited a weaker disruption of lipid metabolism, comparable potency for toxicity to the immune response, and a stronger potency in the extracellular matrix (ECM) destruction along with apoptosis and ferroptosis induction. Hence, our data suggest that F‐53B is more toxic than PFOS to earthworms. The findings provide some new insights into the potential toxicity of F‐53B to soil organisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Toxicological Effects of Perfluorooctane Sulfonate and Its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms

Ge,

Wang,

Chen

et al. 2023

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…For example, there have been reports indicating that the rabies virus infection process in different host cells or the sensitivity of different cell lines to the virus may vary ( 29 – 31 ). However, because of the relatively simple structure of RNA viruses and lack of significant changes in viral morphology observed through electron microscopy in different tissues, tissue cultures, and cell lines ( 32 – 34 ), few studies have analyzed structural changes in the same virus in different cell lines or host cell lines. Ascoviruses are DNA viruses that differ from RNA viruses in their relatively simple structures.…”

Section: Discussionmentioning

confidence: 99%

Flexible changes to the Heliothis virescens ascovirus 3h (HvAV-3h) virion components affect pathogenicity against different host larvae species

Yu,

Chen,

et al. 2023

Microbiol Spectr

View full text Add to dashboard Cite

The pathogenicity of a virus to a specific host species is an inerratic and describable ability of a virus to cause infection but is generally shaped by a variety of abiotic and biotic factors. In this investigation, the variations in pathogenicity of Heliothis virescens ascovirus 3h (HvAV-3h) to five noctuid pests were assessed based on mass spectrometry analysis on the virion compositions. Twenty-nine common HvAV-3h proteins were shared across all hosts, and different flexible proteins were identified in the virions of each specific host. Different host proteins were identified as HvAV-3h virion-associated proteins, including different detoxification enzyme proteins. Furthermore, a relatively fixed relationship between viral replication and changes in host detoxification enzyme activity caused by deficiencies in various viral structural proteins was found in the host larvae using a correlation matrix analysis: the host larval carboxylesterase and cytochrome P450 monooxygenases generally had highly similar responses to the viruses blocked by different structural proteins’ antisera and their effects on viral DNA replication. Different interaction patterns for the virion structural proteins were found in different host larvae-produced virions, and the interactions between Spodoptera litura glutathione S-transferases and viral structural proteins were confirmed. The different host responses after viral infection could be the reason for the changes in viral pathogenicity, while the virus responses gradually adapted to the different hosts and there were flexible changes in the virion structures. IMPORTANCE Different pathogenic processes of a virus in different hosts are related to the host individual differences, which makes the virus undergoes different survival pressures. Here, we found that the virions of an insect virus, Heliothis virescens ascovirus 3h (HvAV-3h), had different protein composition when they were purified from different host larval species. These “adaptive changes” of the virions were analyzed in detail in this study, which mainly included the differences of the protein composition of virions and the differences in affinity between virions and different host proteins. The results of this study revealed the flexible changes of viruses to help themselves adapt to different hosts. Also, these interesting findings can provide new insights to improve our understanding of virus adaptability and virulence differentiation caused by the adaptation process.

show abstract

“…Rabies virus has been shown to cause autophagy in neuronal cells during infection [61]. The accumulation of autophagic vesicles is always observed during RABV infection, and there are two mechanisms regarding the accumulation of autophagic vesicles.…”

Section: Induction Of Autophagy By Rabvmentioning

confidence: 99%

Autophagy and Apoptosis in Rabies Virus Replication

Li,

Xu,

Luo

et al. 2024

Cells

View full text Add to dashboard Cite

Rabies virus (RABV) is a single-stranded negative-sense RNA virus belonging to the Rhabdoviridae family and Lyssavirus genus, which is highly neurotropic and can infect almost all warm-blooded animals, including humans. Autophagy and apoptosis are two evolutionarily conserved and genetically regulated processes that maintain cellular and organismal homeostasis, respectively. Autophagy recycles unnecessary or dysfunctional intracellular organelles and molecules in a cell, whereas apoptosis eliminates damaged or unwanted cells in an organism. Studies have shown that RABV can induce both autophagy and apoptosis in target cells. To advance our understanding of pathogenesis of rabies, this paper reviews the molecular mechanisms of autophagy and apoptosis induced by RABV and the effects of the two cellular events on RABV replication.

show abstract

Regulation of innate immune responses by rabies virus

Cited by 9 publications

References 196 publications

Comparative Toxicological Effects of Perfluorooctane Sulfonate and Its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms

Comparative Toxicological Effects of Perfluorooctane Sulfonate and Its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms

Flexible changes to the Heliothis virescens ascovirus 3h (HvAV-3h) virion components affect pathogenicity against different host larvae species

Autophagy and Apoptosis in Rabies Virus Replication

Contact Info

Product

Resources

About