Regulation of Inflammation in Autoimmune Disease

Duan, Lihua; Rao, Xiaoquan; Sigdel, Keshav Raj

doi:10.1155/2019/7403796

Cited by 103 publications

(74 citation statements)

References 11 publications

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“…However, if the inflammatory process is not resolved, it can lead to chronic inflammation. Lack of inflammation resolution may be due to the continuous presence of self-antigens, as in autoimmune diseases (59).…”

Section: Inflammationmentioning

confidence: 99%

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

et al. 2020

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CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the cytosol, or in intracellular compartments, such as endoplasmic reticulum, nuclear membrane, and mitochondria. The main expression of CD38 is observed in hematopoietic cells, with some cell-type specific differences between mouse and human. The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability. In line with a role in inflammation, CD38 appears to also play a critical role in inflammatory processes during autoimmunity, although whether CD38 has pathogenic or regulatory effects varies depending on the disease, immune cell, or animal model analyzed. Given the complexity of the physiology of CD38 it has been difficult to completely understand the biology of this molecule during autoimmune inflammation. In this review, we analyze current knowledge and controversies regarding the role of CD38 during inflammation and autoimmunity and novel molecular tools that may clarify current gaps in the field.

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Section: Inflammationmentioning

confidence: 99%

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

et al. 2020

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“…The proinflammatory state may be related to hypothyroidism, [ 13 ] hyperthyroidism, [ 14 ] or any common chronic autoimmune pathology like rheumatoid arthritis, inflammatory bowel disease, or gout. [ 15 , 16 ]…”

Section: Comorbidities As a Defining Factor In Morbidity And Mortalitmentioning

confidence: 99%

Sex, sleep, steroids, and lifestyle: Unraveling the coronavirus disease 2019 conundrum

Sehgal

Kalra

Singh

et al. 2020

Journal of Translational Internal Medicine

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Coronavirus disease 2019 (COVID-19) has wreaked havoc and distressed economies worldwide. Countries have gone on lockdown of their economies to prevent the spread of the disease. This obviously led to collateral damage in the form of worsening healthcare for non-COVID-related conditions and is playing havoc with the world economy. Herein, we suggest novel strategies to prevent COVID-19 related complications, keeping in view the pathophysiology of the disease.

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“…Finding a cure for a disease even if it is an infectious one, cancer or a neurodegenerative means to find its root cause. The onset and the development of diseases like allergic asthma [35][36][37], multiple sclerosis, Alzheimer and Parkinson diseases or different forms of cancer [38][39][40] for example have been intensely studied in last decades in relation to the toxicity of different pollutants and especially in relation to the emitted air-borne particles less than PM 2.5. Next, we will try to offer some more details about them and about how their toxicity manifests by modulating our immunity.…”

Section: Pollution Landfill Effectsmentioning

confidence: 99%

Adequate Pollution Management - A Must for Implementation of ‘One Health’ Concept

Arama

Kim

Niță-Lazăr

et al. 2020

RJEEC

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The paper focused on the possible links among pollution, pollution management efficiency including waste management and the propensity of a variety of emerging diseases in our society by answering the question: “How pollution can affect human health?” Environmental pollution is a reality and our planet ecosystem possibilities to face the challenges due to the constant exceeding its resilience are becoming smaller and smaller. The evolution of the climate change indicators like global temperature, global CO2 emissions, oceans acidification and species extinction point out that in a not very long period of time, the planet will not be able to sustain any more the present society’s life style set by the current economic development. Therefore, many warning signals have been issued to change the present behavior in order to reduce significant damages done to the environment and on human health with serious implications on the dysregulation of our immunity and the onset of a plethora of diseases. In this respect, the present paper reviewed relevant aspects linked to the environmental pollution issues that become part of scientific and public debates presented in specialty literature in recent years emphasizing why the implementation of “One Health” concept is necessary.

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Regulation of Inflammation in Autoimmune Disease

Cited by 103 publications

References 11 publications

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

Sex, sleep, steroids, and lifestyle: Unraveling the coronavirus disease 2019 conundrum

Adequate Pollution Management - A Must for Implementation of ‘One Health’ Concept

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