Regulation of inflammation and redox signaling by dietary polyphenols

Rahman, Irfan; Biswas, Saibal K; Kirkham, Paul

doi:10.1016/j.bcp.2006.07.004

Cited by 876 publications

(612 citation statements)

References 82 publications

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“…# P \ 0.05 versus AS-treated cells exposed to mild hyperoxic conditions. AS, human serum obtained after Medox Ò capsules consumption; FS, human serum obtained immediately before Medox Ò capsules consumption known to have beneficial health effects not only for antioxidant activity but also as modulators of the Nrf2 system (Rahman et al 2006;Speciale et al 2011a). However, many currently used in vitro experimental models are able to identify, at cellular and molecular levels, responses induced by phytocomplexes or individual phytochemicals but are usually conducted by adding them directly to the culture medium.…”

Section: Discussionmentioning

confidence: 99%

Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway

et al. 2012

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The detrimental effects of high oxygen supplementation have been widely reported. Conversely, few is known about the effects of exposure to mild hyperoxic conditions, an interesting issue since the use of oxygenenriched mixture is now increasingly used in clinical practice and especially for professional and recreational reasons. Our study investigated if in vitro exposure of human umbilical vein endothelial cells (HUVECs) to moderate hyperoxia (O 2 32 %) induces cellular alterations, measured as changes in cell signaling pathways. Furthermore, by means of an ex vivo experimental model where human volunteers were used as bioreactors, we studied whether anthocyanin metabolites are able to protect HUVECs against mild hyperoxia-induced damage. We observed that the cytotoxic effect of mild hyperoxia came along with a significant decrease in nuclear accumulation of the transcription factor Nrf2, as well as in the expression of Nrf2-regulated antioxidant and cytoprotective genes. Furthermore, under normoxic conditions, anthocyanin metabolites appeared able to activate the Nrf2 pathway, through the involvement of specific kinases (ERK1/2); this adaptive effect may explain the protective effect observed in mild hyperoxia-exposed HUVECs following anthocyanin pretreatment. This study confirms that dietary anthocyanins and/or their metabolites can protect endothelial cells against mild hyperoxia-induced alterations acting as cell signaling modulators.

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Section: Discussionmentioning

confidence: 99%

Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway

et al. 2012

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“…In this study, we investigated the molecular evidence for protecting against cell degeneration with natural compounds under H 2 O 2 treatment conditions in H9c2 cells. Early published papers suggest that resveratrol exerts its biological activities against various diseases through a variety of processes such as ROS scavenging, inhibition of apoptosis or induction of cell survival; however, the underlying mechanisms are poorly understood [4,14].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

et al. 2007

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Resveratrol, one of polyphenols derived from red wine, has been shown to protect against cell death, possibly through the association with several signaling pathways. Currently numerous studies indicate that cardiovascular diseases are linked to the release of intracellular reactive oxygen species (ROS) often generated in states such as ischemia/reperfusion injury. In the present study, we investigated whether resveratrol has the capability to control intracellular survival signaling cascades involving AMP-activated kinase (AMPK) in the inhibitory process of cardiac injury. We hypothesized that resveratrol may exert a protective effect on damage to heart muscle through modulating of the AMPK signaling pathway. We mimicked ischemic conditions by inducing cell death with H 2 O 2 in H9c2 muscle cells. In this experiment, resveratrol induced strong activation of AMPK and inhibited the occurrence of cell death caused by treatment with H 2 O 2 . Under the same conditions, inhibition of AMPK using dominant negative AMPK constructs dramatically abolished the effect of resveratrol on cell survival in H 2 O 2 -treated cardiac muscle cells. These results indicate that resveratrol-induced cell survival is mediated by AMPK in H9c2 cells and may exert a novel therapeutic effect on oxidative stress induced in cardiac disorders.

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“…The high content of phenolic compounds in nuts, particularly in the pellicle, might anticipate an antiinflammatory effect of frequent nut consumption [108], as suggested in cross-sectional studies [43,44,45]. Walnuts could be predicted to be more antiinflammatory than other nuts for two reasons.…”

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

Health Benefits of Nut Consumption

2010

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Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension, cancer, and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect, even in the context of healthy diets, and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity and the metabolic syndrome also appear to be positively influenced by nut consumption. Thus it is clear that nuts have a beneficial impact on many cardiovascular risk factors. Contrary to expectations, epidemiologic studies and clinical trials suggest that regular nut consumption is unlikely to contribute to obesity and may even help in weight loss. Safety concerns are limited to the infrequent occurrence of nut allergy in children. In conclusion, nuts are nutrient rich foods with wide-ranging cardiovascular and metabolic benefits, which can be readily incorporated into healthy diets.

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Regulation of inflammation and redox signaling by dietary polyphenols

Cited by 876 publications

References 82 publications

Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway

Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

Health Benefits of Nut Consumption

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