Regulation of Immunoglobulin Gene Rearrangement

Köhler, Georges; Iglesias, Antonio; Lamers, R.; Köpf, Manfred; Bühler, Bernd; Fritzsche, Ulrike

doi:10.1007/978-3-642-83755-5_43

Cited by 3 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Residues of the D-JH encoded region have previously been shown to be involved in the interaction with the L chainvdomains [31]. Properly folded, the D-JH might similarly interact with the FR2-FR3 homologous regions of the V, , B and the J homologous region of h5 and thus be involved in signalling productive VH rearrangements [32].…”

Section: Discussionmentioning

confidence: 98%

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

Abergel

Claverie

1991

Eur J Immunol

View full text Add to dashboard Cite

A compilation of murine and human Ig H and TcR beta D segment sequences was used to estimate the relative usage of the various reading frames and to look for associated sequence patterns. We confirm a strong bias in the expression of the Ig H D segments, with more than 90% (murine) and 85% (human) expressed peptides resulting from a preferred reading frame. Remarkably, 86% (mouse) and 90% (human) of those peptides contain at least one glycine residue. All but one of the atypical preferred D peptides contain serine or proline residues and are found in the immediate vicinity of glycine residues provided by specific JH segments. The presence of tyrosine residues is also a characteristic feature of expressed reading frames in both mouse (75%) and human (90%). These results suggest that the constraints of forming a flexible loop within the third complementarity-determining region, is a factor in the preference for a particular reading frame in Ig H D. For the TcR beta D segments, glycine is specified in most reading frames, and no significant preference is observed.

show abstract

Section: Discussionmentioning

confidence: 98%

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

Abergel

Claverie

1991

Eur J Immunol

View full text Add to dashboard Cite

show abstract

“…In efforts to understand the mechanisms controlling Ig gene usage, a number of hypothesis has been put forward. These studies have provided many important insights, but have yet to yield a precise mechanism (Holmberg et al, 1986;Kearney and Vakil, 1986;Manser and Gefter, 1986;Wu and Paige, 1988;Kohler et al, 1989;Leclercq et al, 1989;Grandien et al, 1990;Andrade et al, 1991;Tsubata et al, 1991;Kottman et al, 1992;Viale et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Several re-ports have appeared that indicate that the utilization of DH families are different from that expected based on chance alone (Yancopoulos et al, 1988;Nickerson et al, 1989; Feeney, 1990Feeney, , 1992Gu et al, 1990;Tsukada et al, 1990;Reynaud et al, 1991;Rolink et al, 1991;Carlsson et al, 1992; Chang et al, 1992). This raises the possibility that selective events, as yet undefined, influence significantly the generation of immunoglobulin diversity (Kohler et al, 1989;Rolink et al, 1991; Kottman et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Overusage of Mouse DH Gene Segment, DFL16.1, IsStrain‐Dependent and Determined by cis‐Acting Elements

Atkinson

Chang

Celler

et al. 1993

Journal of Immunology Research

View full text Add to dashboard Cite

The DJH structure is of particular importance for diversity in the immunoglobulin heavy chain because it encodes most of CDR3. Here, we investigate mechanisms responsible for generating the DJH structure. We found DFL16.1 was used at a high frequency in normal and transformed pre-B cells (fetal liver > 50%, A-MuLV lines ≅ 25%). One DFL16.1JH1 structure was found repeatedly and was also present in DJH and VDJH databases, suggesting this structure may be conserved in the primary repertoire. Genetic analysis demonstrated that C57BL/6 mice use DFL16.1 in DJH structures more frequently than BALB/c. Examination of individual alleles in (C57BL/6 BALB/c)F1 A-MuLV cell lines revealed that the C57BL/6-derived allele used DFL16.1 twice as often as the BALB/c. This result indicates that part of the mechanism ensuring overusage of DFL16.1 gene segments is cis-acting.

show abstract

Fetal versus Adult PreB or B Cells: The Human VH Repertoire^a

Tonnelle

Cuisinier

Gauthier

et al. 1995

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Regulation of Immunoglobulin Gene Rearrangement

Cited by 3 publications

References 18 publications

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

Overusage of Mouse DH Gene Segment, DFL16.1, IsStrain‐Dependent and Determined by cis‐Acting Elements

Fetal versus Adult PreB or B Cells: The Human VH Repertoire^a

Contact Info

Product

Resources

About

Regulation of Immunoglobulin Gene Rearrangement

Cited by 3 publications

References 18 publications

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

Overusage of Mouse DH Gene Segment, DFL16.1, IsStrain‐Dependent and Determined by cis‐Acting Elements

Fetal versus Adult PreB or B Cells: The Human VH Repertoirea

Contact Info

Product

Resources

About

Fetal versus Adult PreB or B Cells: The Human VH Repertoire^a