Regulation of immunity and autoimmunity by B cells

Mauri, Claudia

doi:10.1016/j.coi.2010.10.009

Cited by 111 publications

(87 citation statements)

References 56 publications

(61 reference statements)

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“…For this reason the deep knowledge of B cell subsets and functions provides crucial information on immune assessment. Moreover B lymphocytes, due to their ability to present antigen to T lymphocytes, produce cytokines and synthesize granzymes, are now recognized as eclectic and essential cells for an exhaustive immune response (Blair et al, 2010;Bouaziz et al, 2010;Buffa et al, 2011;Hagn et al, 2009Mauri, 2010;Vitale et al, 2010). The different B cell subsets have been identified using many cellular markers by which many functional subsets, as transitional, naïve, memory and plasmablasts may be recognized.…”

Section: Introductionmentioning

confidence: 99%

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Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly

Bulati

Buffa

Martorana

et al. 2014

Experimental Gerontology

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The impairment of humoral immune response in elderly humans has been extensively demonstrated. We have reported the increase of memory B cells (IgG, double negative, DN) population in the elderly, in which there is also a typical inflammatory micro-environment. In order to evaluate whether this pro-inflammatory status could influence the trafficking phenotype of naïve/memory B cells, we have assessed the expression of CCR7, CCR6, CXCR3, CXCR4, CXCR5 and CD62L on naïve/memory B cell subpopulations in young and elderly subjects. Moreover, the combination of pro-inflammatory interleukin-21 (IL-21) and B cell receptor (BCR) stimulation enables B cells to produce and secrete granzyme B (GrB), which plays a critical role in early anti-viral immune responses, in the regulation of autoimmune mechanisms and in cancer immunosurveillance. Our data demonstrate that in the elderly, naïve/memory B cell populations present a different expression of the studied receptors that could be discussed in terms of "inflamm-aging". In particular IgGshow a tissue trafficking phenotype and they can be stimulated to produce GrB.

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Section: Introductionmentioning

confidence: 99%

“…The defects in B cell production/development cause a variety of disorders that are the basis of immune deficiencies and/or autoimmune diseases (Blair et al, 2010;Mauri, 2010;Vitale et al, 2010). For this reason the deep knowledge of B cell subsets and functions provides crucial information on immune assessment.…”

Section: Introductionmentioning

confidence: 99%

Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly

Bulati

Buffa

Martorana

et al. 2014

Experimental Gerontology

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“…However, specific B-cell subsets can also negatively regulate T-cell immune responses, and have been termed regulatory B cells (Breg) [1][2][3] . A part of the humoral immune response is the interaction between follicular helper T cells (T FH cells) and cognate B cells to drive the formation and maintenance of germinal centre (GC) reactions [4][5][6][7] .…”

mentioning

confidence: 99%

PD-L1hi B cells are critical regulators of humoral immunity

et al. 2015

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Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4 þ CXCR5 þ PD-1 þ follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to aCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases.

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“…There is increasing evidence that B-cells play important dual opposing roles in the immune response to tumours; on the one hand as antigen presenting cells and producers of cytotoxic antibodies effective at killing tumour cells by antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cell lysis, and as tumour antigen-presenting cells capable of very efficient T-cell activation; on the other hand as promoters of inflammation aiding tumour progression (de Visser, Korets, & Coussens, 2005;de Visser, Eichten, & Coussens, 2006). These seemingly contradictory effects may be due to the difference between a specific, high affinity immune response to antigen versus a low affinity, polyclonal response, or even suppression of the cytotoxic immune response via regulatory B-cells (Mauri, 2010). The importance of antibodies in eliminating tumours is clearly demonstrated by the results of treatment of breast cancer patients with humanised monoclonal antibodies (MAbs) specific for the epidermal growth factor receptor HER-2 (trastuzumab/herceptin and pertuzumab).…”

Section: The Immune Response To Breast Cancermentioning

confidence: 99%