Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs

Khan, Deena; Ahmed, S. Ansar

doi:10.3389/fgene.2015.00236

Cited by 54 publications

(46 citation statements)

References 129 publications

(131 reference statements)

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“…Recently, some studies have elucidated the regulation role of IL-17 and the plausible interplay between IL-17 and miRNA in multiple diseases [23]. The potential relationship between IL-17 and miRNA may facilitate the diagnosis and therapy of the disease.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

Cao

Zhao

et al. 2017

Cell Physiol Biochem

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Aim: The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported in the literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. Our study aimed to investigate the interaction between IL-17 and miR-181a-5p in NSCLC. Methods: 35 patients with NSCLC and 24 COPD controls were selected and examined in our study. In vitro, H226 and H460 cell lines were exposed to different doses (20, 40, 60, and 80 ng/mL) of IL-17 to examine the effect of IL-17 on miR-181a-5p and vascular cell adhesion molecule 1 (VCAM-1) expression. MiR-181 mimic and miR-181a-5p inhibitor were transfected to explore the regulation of VCAM-1 as well as tumor cell proliferation and migration. Results: miR-181a-5p expression was downregulated, and IL-17 and VCAM-1 expression was upregulated in NSCLC tissues. Furthermore, IL-17 decreased miR-181a-5p expression but increased VCAM-1 expression in H226 and H460 cells. MiR-181 regulated VCAM-1 expression through binding to 3’-UTR sequence. MiR-181 attenuated tumor cell proliferation and migration. IL-17 modulated miR-181a-5p expression through activating NF-κB but not Stat3. Conclusion: Taken together, our data show the regulation of VCAM-1 expression by miR-181a-5p under IL-17 exposure, predicting a potential way for counteracting cancer metastasis.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

Cao

Zhao

et al. 2017

Cell Physiol Biochem

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“…These are pro-inflammatory cytokines differentiated from naïve CD4 + T cells that promote inflammation in autoimmune diseases through stimulation of inflammatory mediator production, as well as other immunological responses, such as imbalance between Th17, regulatory mechanisms, and Th1 response. [28][29][30]31] IL-17 secretion are likely to disrupt the delicate balance of islet T cells in favor of autoimmune inflammatory destruction. [26] The increased levels of IL-17 in T1D may be attributed to the presence of pro-inflammatory cytokine milieu that drives toward Th17 differentiation.…”

Section: Discussionmentioning

confidence: 99%

Increased Level of Interleukin-17 in Children and Adolescents with Type 1 Diabetes Mellitus and its Association with Vitamin D Deficiency

Tjahjono¹,

Farida²

2019

Turk J Immunol

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Introduction:The up-regulation of interleukin-17 (IL-17) has been reported to be the pathogenesis of type 1 diabetes mellitus (T1D). On the other hand, vitamin D deficiency is fairly prevalent in T1D. This study aims to investigate IL-17 and vitamin D status and its correlation in children and adolescents with T1D. Material and Methods:A cross sectional study was carried out between January to March 2017. A total of 20 patients aged 12.25±3.74 years old with T1D and 20 healthy control group were involved. Their parents signed an informed consent. Demographic data were obtained using structured questionnaires. Physical, and laboratory examination were also performed. Blood samples were collected and serum vitamin D and IL-17 levels were measured by indirect ELISA were. Results:The serum level of vitamin D serum and IL-17 level between both groups were significantly different (p<0.001). A positive correlation between vitamin D and IL-17 levels (p<0.05; r=+0.566) was found.Conclusion: T1D is a T cell-mediated autoimmune disorder which targets and destroys insulin-producing pancreatic beta-cells. Children and adolescents with T1D show an increased level of IL-17 immunity and vitamin D deficiency. IL-17 immunity control and vitamin D supplementation could be potential targets for further development of T1D therapeutic strategies. ÖzGiriş: Tip 1 Diabetes Mellitus (T1D)'un patogenezinde İnterlökin 17(IL-17)'nin artışının rolü olduğu bildirilmiştir. Öte yandan, T1D'lu hastalarda çoğunlukla D vitamini eksikliği saptanır. Bu çalışmada amaç, çocuk ve ergen T1D'li hastalarda IL-17 ve D vitamininin düzeylerini araştırmaktır. Gereçler ve Yöntemler: Çalışmada, 2017 Ocak ayı ile 2017 Mart ayı arasındaki hastalar çapraz kesitsel olarak irdelendi. Yaşları 12.25±3.74 arasında olan toplam 20 T1D'li olgu ile 20 sağlıklı birey kontrol grubu olarak çalışmaya dahil edildi. Hastaların ebeveynleri çalışmaya katılmak için bilgilenmiş onay verdi. Olguların demografik verileri oluşturulmuş anket formlarının doldurulması ile elde edildi. Ayrıca fizik muayene bulguları ve laboratuvar değerleri kaydedildi. Olgulardan kan alınarak indirekt ELISA yöntemi ile kan D vitamini ve IL-17 seviyeleri ölçüldü. Bulgular: D vitamini ve IL-17 seviyeleri 2 grup arasında karşılaştırıldığında istatistiksel olarak anlamlı derecede farklılık gözlendi (p<0.001). Vitamin D ve IL-17 seviyeleri arasında pozitif bağlantı saptandı (p<0.005; r:+0.566) Sonuç: T1D, T lenfositlerinin pankreasta insülin salgılayan beta hücrelerini hedefleyerek harap ettiği T-hücresine bağlı bir otoimmün hastalıktır. Çocuk ve erişkin TID hastalarında IL-17 düzeylerinde artış, D vitamini düzeylerinde azalma gözlenmiştir. T1D'nin tedavisinde IL-17'ye bağlı immünitenin hedeflenmesi ve hastalara D vitamini verilmesi önerilebilir. Anahtar Kelimeler: Tip 1 Diabetes Mellitus, İnterlökin-17, D Vitamini 36. Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, et al. 1.25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote developmentof regul...

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“…Positive correlations in miRNA expression and IL-17 levels have been observed in different studies (Khan & Ansar Ahmed, 2015).…”

Section: Mi-rna and Th17 Cellsmentioning

confidence: 96%

Promising Epigenetic Approaches Targeting TH17 in Autoimmune Diabetes among Chronic Hepatitis C Infection

Hetta¹,

Elkady²

2017

Int.J.Curr.Microbiol.App.Sci

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Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs

Cited by 54 publications

References 129 publications

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

Increased Level of Interleukin-17 in Children and Adolescents with Type 1 Diabetes Mellitus and its Association with Vitamin D Deficiency

Promising Epigenetic Approaches Targeting TH17 in Autoimmune Diabetes among Chronic Hepatitis C Infection

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