Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster

Huang, Xiande; Dai, Jia‐Ge; Lin, Ke-tao; Liu, Mei; Ruan, Huada Daniel; Zhang, Hua; Liu, Wenguang; He, Maoxian; Zhao, Mei‐Jun

doi:10.1016/j.fsi.2018.07.020

Cited by 19 publications

(9 citation statements)

References 32 publications

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“…These results suggest the existence of a modified immune response of mussels after the second challenge oriented to tolerate [81,82], and it has been recently published the mechanism to generate small RNAs in mussels and oysters by Rosani et al [83]. These non-coding RNAs can alter, among other physiological processes, the immune response [84,85]. Both, epigenetics and non-coding RNAs, are current challenges in bivalve research which will deliver interesting results in the next years.…”

Section: Mussel Immune System Is In Permanent Contact With Microorganmentioning

confidence: 81%

Genomics and immunity of the Mediterranean mussel Mytilus galloprovincialis in a changing environment

Figueras

Moreira

Sendra

et al. 2019

Fish & Shellfish Immunology

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Section: Mussel Immune System Is In Permanent Contact With Microorganmentioning

confidence: 81%

Genomics and immunity of the Mediterranean mussel Mytilus galloprovincialis in a changing environment

Figueras

Moreira

Sendra

et al. 2019

Fish & Shellfish Immunology

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“…The secretions of IL-1b and IL-17 were inhibited after Listeria infection in Clec5a( 2/2 ) mice (38). Recently, some proinflammatory cytokines like IL-17s and TNF have also been identified in mollusks with crucial roles in defending against bacterial invasion (23,(25)(26)(27). However, the receptors to recognize bacteria and promote IL-17 and TNF production are still not well known in mollusks.…”

Section: Discussionmentioning

confidence: 99%

“…IL-17 exhibits Ag-presenting, antibacterial, and cytotoxic activities in T cells (20,21) and promotes the secretions of multiple other cytokines, including IL-1a, IL-6, IL-23, and TNF-a (22). Recently, some proinflammatory factors, like IL-17s and TNF, have also been identified in mollusks (23)(24)(25)(26)(27). IL-17s and TNF in Pacific oyster Crassostrea gigas and pearl oyster Pinctada fucata were reported to play important roles in mediating the clearance of extracellular bacteria (23,25,27).…”

mentioning

confidence: 99%

“…Recently, some proinflammatory factors, like IL-17s and TNF, have also been identified in mollusks (23)(24)(25)(26)(27). IL-17s and TNF in Pacific oyster Crassostrea gigas and pearl oyster Pinctada fucata were reported to play important roles in mediating the clearance of extracellular bacteria (23,25,27). However, the detailed mechanism of immune recognition and the downstream signaling pathway to regulate IL-17 and TNF production are still unclear in invertebrates.…”

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confidence: 99%

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CgCLec-HTM–Mediated Signaling Pathway Regulates Lipopolysaccharide-Induced CgIL-17 and CgTNF Production in Oyster

Sun

Wang

Huang

et al. 2019

The Journal of Immunology

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The immune signaling pathway mediated by Dectin-1 is important in mammals to modulate the production of IL-17 and TNF-a. Recently, IL-17 and TNF have also been characterized in invertebrates to play crucial roles in antibacterial immune responses, although the immune recognition and regulation mechanisms to produce IL-17 and TNF are still not well investigated. In the current study, a novel C-type lectin receptor (named CgCLec-HTM) with a signal peptide, a carbohydrate recognition domain, a transmembrane domain, and a nonclassical ITAM (hemITAM) in the cytoplasmic tail was identified from oyster Crassostrea gigas. CgCLec-HTM could bind LPS and various bacteria. After binding to its ligands, CgCLec-HTM was associated with the Src homology 2 (SH2) domain of spleen tyrosine kinase (CgSyk) by the hemITAM in its cytoplasmic tail to promote ERK (CgERK) phosphorylation. The activated CgERK could interact with CgRel to induce CgRel nuclear translocation. The CgRel in the nucleus eventually induced the transcription of CgIL-17s and CgTNF. The results demonstrated that CgCLec-HTM with a broad binding spectrum of bacteria could be associated with CgSyk to transfer immune signals into the intracellular ERK-Rel pathway to induce CgIL-17 and CgTNF production.

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“…Consistently, in the present study, the upregulation of IL-17 was observed in RA patients when compared to that noted in healthy controls. It is known that IL-17 may interact with lncRNAs to participate in biological processes (16,17). At present, the molecular mechanisms of the actions of lncRNAs in RA remain largely unknown.…”

Section: Discussionmentioning

confidence: 99%

lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast‑like synoviocytes by downregulating IL‑17

et al. 2020

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lncrna cancer susceptibility candidate 2 (caSc2) is a recently identified oncogenic lncRNA in different types of cancers. Our preliminary microarray data showed that lncRNA CASC2 was downregulated in the plasma of patients with rheumatoid arthritis (RA), indicating the involvement of this lncRNA in RA. In the present study, lncRNA CASC2 and IL-17 in plasma were detected by reverse transcription-quantitative PCR and ELISA, respectively. Diagnostic analyses were performed using receiver operating characteristic curves. Flow cytometry was performed to evaluate cell apoptosis. The effects of lncRNA CASC2 on IL-17 expression were determined via western blotting. lncRNA CASC2 was found to be downregulated, while IL-17 was upregulated in the plasma of RA patients when compared with these levels in the plasma of healthy controls. Plasma levels of lncRNA CASC2 and IL-17 were significantly and inversely correlated in both RA patients and healthy controls. Altered plasma levels of lncRNA CASC2 and IL-17 were able to differentiate RA patients from healthy controls. Overexpression of lncRNA CASC2 promoted, while treatment with IL-17 inhibited the apoptosis of human fibroblast-like synoviocytes (HFLSs) isolated from RA patients. Overexpression of lncRNA CASC2 inhibited IL-17 expression in HFLS, while treatment with IL-17 did not significantly affect the expression of lncRNA CASC2. Therefore, downregulation of lncRNA CASC2 is involved in RA and lncRNA CASC2 overexpression may promote the apoptosis of HFLS by downregulating IL-17.

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Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster

Cited by 19 publications

References 32 publications

Genomics and immunity of the Mediterranean mussel Mytilus galloprovincialis in a changing environment

Genomics and immunity of the Mediterranean mussel Mytilus galloprovincialis in a changing environment

CgCLec-HTM–Mediated Signaling Pathway Regulates Lipopolysaccharide-Induced CgIL-17 and CgTNF Production in Oyster

lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast‑like synoviocytes by downregulating IL‑17

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