Regulation of IgE‐receptor expression, IgE occupancy and secretory capacity of mast cells

Chen, Xiao‐Jun; Enerbäck, Lennart

doi:10.1034/j.1600-0463.2000.d01-9.x

Cited by 5 publications

(3 citation statements)

References 52 publications

(56 reference statements)

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“…(13;24) We hypothesized that FAHF-2 might directly suppress IgE-mediated up-regulation of FcεRI expression. To address this possibility we employed the well-characterized murine mast cell line MC/9 treated with DNP specific IgE.…”

Section: Resultsmentioning

confidence: 99%

Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils

Song

Srivastava

et al. 2010

Journal of Allergy and Clinical Immunology

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Background Mast cells and basophils are key effector cells of IgE-mediated anaphylactic reactions. The Chinese herbal formula, FAHF-2, protects against peanut anaphylaxis in mice. However, the mechanisms underlying this effect are not fully elucidated. Objective To investigate whether FAHF-2 inhibits mast cell/basophil numbers and IgE mediated activation. Methods Peanut allergic mice (PNA mice) were treated with FAHF-2 intragastrically (i.g.) for 7 weeks and challenged (i.g.) with peanut 1 day and 4 weeks post treatment. Peripheral blood basophil numbers and peritoneal mast cell numbers and FcεRI expression were determined. Direct effects of FAHF-2 on murine mast cell line MC/9, and effects of four fractions and three compounds isolated from FAHF-2 on rat basophilic leukemia cells (RBL-2H3) and human skin mast cells degranulation, and on the IgE mediated Syk signaling pathway were determined. Results While all sham-treated PNA mice developed anaphylaxis, FAHF-2-treated PNA mice were protected against anaphylaxis following peanut challenge at 1 day and 4 weeks post therapy. Reduction of peripheral blood basophils began after 1 week of treatment and continued for at least 4 weeks post therapy. The number and FcεRI expression of peritoneal mast cells were also significantly decreased 4 weeks post therapy. FAHF-2 treated MC/9 cells showed significantly reduced IgE-induced FcεRI expression, FcεRI γ mRNA subunit expression, proliferation, and histamine release upon challenge. Fraction 2 (F2) from FAHF-2 inhibited RBL-2H3 cell and human mast cell degranulation. Three compounds from F2- berberine, palmatine and jatrorrhizine inhibited of RBL-2H3 cell degranulation via suppressing Syk phosphorylation. Conclusion FAHF-2 reduction of basophils and mast cell numbers as well as suppression of IgE-mediated mast cell activation may contribute to FAHF-2 persistent protection against peanut anaphylaxis. Clinical Implications FAHF-2 blocked peanut anaphylaxis. This effect was associated with reduction of mast cells/basophils activation and proliferation. FAHF-2 may be a novel anti-peanut anaphylaxis therapy.

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Section: Resultsmentioning

confidence: 99%

Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils

Song

Srivastava

et al. 2010

Journal of Allergy and Clinical Immunology

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“…Mast cells degranulation evokes local immediate hyperergic reaction [108,109]. This reaction starts when immunoglobulines, mainly IgE, are fixing to specific receptors of mast cells [110,111]. Cells producing IgE are localized in lymphoid tissue, ears, nose, oral cavity and upper respiratory tract mucous membrane [112].…”

Section: Methodsmentioning

confidence: 99%

Aetiology and Pathogenesis of Trigeminal Neuralgia: a Comprehensive Review

Sabalys¹,

Juodžbalys²,

Wang

2012

JOMR

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ObjectivesThe aim of present paper was to discuss issues related to trigeminal neuralgia with strong emphasis on the aetiology and pathogenesis of this problem.Material and MethodsAn electronic search of 5 databases (1965 - Oct 2012) and a hand search of peer-reviewed journals for relevant articles were performed. In addition, experience acquired from treating 3263 patients in the Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, were also summarized.ResultsGenerally, aetiological factors can be classified into 3 most popular theories that were based on: 1) Related to other disease, 2) Direct injury to the trigeminal nerve, and 3) Propagates the polyetiologic origin of the disease. In addition, two pathogenesis mechanisms of trigeminal neuralgia were proposed. First: the peripheral pathogenetic mechanism that is often induced by progressive dystrophy around the peripheral branches of the trigeminal nerve. Second, central pathogenetic mechanism which often triggered by peripheral pathogen that causes long-lasting afferent impulsation and the formation of a stable pathologic paroxysmal type irritation focus on the central nerve system (CNS).ConclusionsPatients with susceptive trigeminal neuralgia should be examined carefully by specialists who have expertise in assessing and diagnosing of possible pathological processes and be able to eliminate the contributing factors so the trigeminal neuralgia can be properly managed.

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“…As recently found, a small amount of IgE is produced spontaneously by healthy individuals and may conceivably play a regulatory role. This is indicated by the fact that the IgE receptors of most mast cells are occupied [65]. …”

Section: ‘Common Mucosal Immune System’ – Secretory Iga – Local Produmentioning

confidence: 99%

Mucosal Immunity: Its Role in Defense and Allergy

Tlaskalová‐Hogenová

Tučková²,

Lodinová-Žádníková³

et al. 2002

Int Arch Allergy Immunol

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The interface between the organism and the outside world, which is the site of exchange of nutrients, export of products and waste components, must be selectively permeable and at the same time, it must constitute a barrier equipped with local defense mechanisms against environmental threats (e.g. invading pathogens). The boundaries with the environment (mucosal and skin surfaces) are therefore covered with special epithelial layers which support this barrier function. The immune system, associated with mucosal surfaces covering the largest area of the body (200–300 m²), evolved mechanisms discriminating between harmless antigens and commensal microorganisms and dangerous pathogens. The innate mucosal immune system, represented by epithelial and other mucosal cells and their products, is able to recognize the conserved pathogenic patterns on microbes by pattern recognition receptors such as Toll-like receptors, CD14 and others. As documented in experimental gnotobiotic models, highly protective colonization of mucosal surfaces by commensals has an important stimulatory effect on postnatal development of immune responses, metabolic processes (e.g. nutrition) and other host activities; these local and systemic immune responses are later replaced by inhibition, i.e. by induction of mucosal (oral) tolerance. Characteristic features of mucosal immunity distinguishing it from systemic immunity are: strongly developed mechanisms of innate defense, the existence of characteristic populations of unique types of lymphocytes, colonization of the mucosal and exocrine glands by cells originating from the mucosal organized tissues (‘common mucosal system’) and preferential induction of inhibition of the responses to nondangerous antigens (mucosal tolerance). Many chronic diseases, including allergy, may occur as a result of genetically based or environmentally induced changes in mechanisms regulating mucosal immunity and tolerance; this leads to impaired mucosal barrier function, disturbed exclusion and increased penetration of microbial, food or airborne antigens into the circulation and consequently to exaggerated and generalized immune responses to mucosally occurring antigens, allergens, superantigens and mitogens.

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Regulation of IgE‐receptor expression, IgE occupancy and secretory capacity of mast cells

Cited by 5 publications

References 52 publications

Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils

Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils

Aetiology and Pathogenesis of Trigeminal Neuralgia: a Comprehensive Review

Mucosal Immunity: Its Role in Defense and Allergy

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