Regulation of <i>Sox8</i> through lncRNA <i>Mrhl</i>-Mediated Chromatin Looping in Mouse Spermatogonia

Kayyar, Bhavana; Ravikkumar, Anjhana C; Bhaduri, Utsa; M, Rao

doi:10.1128/mcb.00475-21

Cited by 4 publications

(1 citation statement)

References 51 publications

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“…The transcription factor SOX8, which belongs to the SRY-related HMG Box (SOX) family, was initially discovered as the sex determination gene and has been found to play a role in the fertility of adult mice [ 25 ]. Recent studies have revealed that SOX8 possesses a distinct capability to govern the development of the ear [ 26 ], as well as the differentiation of M cells and the activation of mucosal immune responses mediated by IgA [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis

Yang,

Gu,

Cai

et al. 2024

Redox Biology

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Section: Introductionmentioning

confidence: 99%

Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis

Yang,

Gu,

Cai

et al. 2024

Redox Biology

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PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene

Sato,

Satoh,

Yamamoto

et al. 2024

Gene

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Nuclear lncRNA NORSF reduces E2 release in granulosa cells by sponging the endogenous small activating RNA miR-339

Wang,

Yang

et al. 2023

BMC Biol

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Background Functioning as a competing endogenous RNA (ceRNA) is the main action mechanism of most cytoplasmic lncRNAs. However, it is not known whether this mechanism of action also exists in the nucleus. Results We identified four nuclear lncRNAs that are presented in granulosa cells (GCs) and were differentially expressed during sow follicular atresia. Notably, similar to cytoplasmic lncRNAs, these nuclear lncRNAs also sponge miRNAs in the nucleus of GCs through direct interactions. Furthermore, NORSF (non-coding RNA involved in sow fertility), one of the nuclear lncRNA acts as a ceRNA of miR-339. Thereby, it relieves the regulatory effect of miR-339 on CYP19A1 encoding P450arom, a rate-limiting enzyme for E2 synthesis in GCs. Interestingly, miR-339 acts as a saRNA that activates CYP19A1 transcription and enhances E2 release by GCs through altering histone modifications in the promoter by directly binding to the CYP19A1 promoter. Functionally, NORSF inhibited E2 release by GCs via the miR-339 and CYP19A1 axis. Conclusions Our findings highlight an unappreciated mechanism of nuclear lncRNAs and show it acts as a ceRNA, which may be a common lncRNA function in the cytoplasm and nucleus. We also identified a potential endogenous saRNA for improving female fertility and treating female infertility.

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Regulation of Sox8 through lncRNA Mrhl-Mediated Chromatin Looping in Mouse Spermatogonia

Cited by 4 publications

References 51 publications

Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis

Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis

PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene

Nuclear lncRNA NORSF reduces E2 release in granulosa cells by sponging the endogenous small activating RNA miR-339

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