Regulation of human hydrolases and its implications in pharmacokinetics and pharmacodynamics
Sun Min Jung,
Hao-Jie Zhu
Abstract:Hydrolases represent an essential class of enzymes indispensable for the metabolism of various clinically essential medications. Individuals exhibit marked differences in the expression and activation of hydrolases, resulting in significant variability in the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs metabolized by these enzymes. The regulation of hydrolase expression and activity involves both genetic polymorphisms and nongenetic factors. This review examines the current understanding of geneti… Show more
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