Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4

Luis, Nuno Miguel; Morey, Lluís; Mejetta, Stefania; Pascual, Gloria; Janich, Peggy; Kuebler, Bernd; Cozutto, Luca; Roma, Guglielmo; Nascimento, Elisabete; Frye, Michaela; Croce, Luciano Di; Benitah, Salvador Aznar

doi:10.1016/j.stem.2011.09.014

Cited by 23 publications

(32 citation statements)

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“…PRC1 complex member RING1B catalyses mono‐ubiquitination on H2A (H2AK119ub) and recognizes H3K27me3 marks for gene silencing . PRC1‐associated protein CBX4 is required for maintaining human epidermal SCs in a slow‐cycling and undifferentiated state . Further studies showed reduced keratinocyte proliferation and increased premature differentiation upon Cbx4 deletion in mouse epidermis at E16.5 .…”

Section: Histone Methylation In Skin Development and Homeostasismentioning

confidence: 99%

“…Also, Cbx4 regulates epidermal SC fate determination by suppressing non‐epidermal lineage genes . Functional studies of mutant Cbx4 showed hyperproliferation and increased senescence in human keratinocytes through increased Cdkn2a/p16 transcripts . Moreover, transplantation of Cbx4‐depleted keratinocytes failed to reconstitute the full mouse epithelium, indicating its significance in epidermal SC maintenance .…”

Section: Histone Methylation In Skin Development and Homeostasismentioning

confidence: 99%

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Epigenetic control in skin development, homeostasis and injury repair

Kang

Chovatiya

Tumbar

2019

Experimental Dermatology

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Cell‐type‐ and cell‐state‐specific patterns of covalent modifications on DNA and histone tails form global epigenetic profiles that enable spatiotemporal regulation of gene expression. These epigenetic profiles arise from coordinated activities of transcription factors and epigenetic modifiers, which result in cell‐type‐specific outputs in response to dynamic environmental conditions and signalling pathways. Recent mouse genetic and functional studies have highlighted the physiological significance of global DNA and histone epigenetic modifications in skin. Importantly, specific epigenetic profiles are emerging for adult skin stem cells that are associated with their cell fate plasticity and proper activity in tissue regeneration. We can now begin to draw a more comprehensive picture of how epigenetic modifiers orchestrate their cell‐intrinsic role with microenvironmental cues for proper skin development, homeostasis and wound repair. The field is ripe to begin to implement these findings from the laboratory into skin therapies.

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Section: Histone Methylation In Skin Development and Homeostasismentioning

confidence: 99%

Section: Histone Methylation In Skin Development and Homeostasismentioning

confidence: 99%

Epigenetic control in skin development, homeostasis and injury repair

Kang

Chovatiya

Tumbar

2019

Experimental Dermatology

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“…c-Myc, a mammalian viral oncogene homolog, is one of the activators of the epidermal stem cell population [16]. The authors implicated both polycomb-dependent, as well as independent, functions of Cbx4 in regulation of epidermal stem cell activity and senescence [16].…”

Section: Introductionmentioning

confidence: 99%

“…The authors implicated both polycomb-dependent, as well as independent, functions of Cbx4 in regulation of epidermal stem cell activity and senescence [16]. AHR has been shown to constitutively repress c-myc transcription by binding to its promoter in mammary tumor cells [17].…”

Section: Introductionmentioning

confidence: 99%

TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

Mandavia

2015

Medical Hypotheses

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“…For a long time, Polycomb products were considered exclusively as developmental regulators. Importantly, Polycomb regulates self-renewal of pluripotent progenitors and proliferative of their differentiated progeny contributing to tissue homeostasis (Calés et al 2008;Klauke et al 2013;Lessard and Sauvageau 2003;Luis et al 2011). Polycomb targets include genes associated with transitions within cell lineages on their way to full differentiation.…”

Section: Introductionmentioning

confidence: 99%