Regulation of Human Breast Cancer by Secreted Growth Factors

Cullen, Kevin J.; Yee, Douglas; Bates, Susan E.; Brünner, N.; Clarke, Robert; Rb, Dickson; Huff, Kenneth R.; Paik, Soonmyoung; Kosen, N.; Valverius, Eva M.; Zugmaier, Gerhard; Lippman, Marc E.

doi:10.3109/02841868909092318

Cited by 21 publications

(10 citation statements)

References 21 publications

(13 reference statements)

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“…Abnormal stimulation by regulatory factors may contribute to malignant progression through de novo autocrine loops, or by deregulation of existing paracrine interactions (Cullen et al, 1989). Indeed, in addition to hormonal control, a variety of such autocrine and paracrine interactions seem to affect the growth of mammary gland cells (Adams et al, 1988;Kern et al, 1990;Van Roozendaal et al, 1992;Ryan et al, 1993).…”

mentioning

confidence: 99%

Expression of the FGFR1 gene in human breast‐carcinoma cells

Jacquemier

Adélaı̈de

Parc

et al. 1994

Intl Journal of Cancer

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Fibroblast growth factors (FGF) constitute a family of at least 9 members which act through high-affinity tyrosine-kinase receptors encoded by 4 distinct genes. In humans, the FGFR1 gene is located in chromosomal region 8p12. Its amplification and expression were examined in a panel of 110 breast carcinoma samples by Southern- and Northern-blot analyses. FGFR1 was amplified in 9% and overexpressed in about 15% of the tumors studied. In situ hybridization experiments were performed on tissue sections of normal breast and tumors with a high level of FGFR1 expression. In both normal and tumoral tissues, FGFR1 RNA was detected in the epithelial cells. Overexpression of FGFR1 seems to be associated with small, well-differentiated diploid tumors.

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confidence: 99%

Expression of the FGFR1 gene in human breast‐carcinoma cells

Jacquemier

Adélaı̈de

Parc

et al. 1994

Intl Journal of Cancer

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“…There is evidence for autocrine control of human breast cancer growth, through endogenous or oestrogen controlled production of polypeptide growth factors (Lippman et al, 1986a;1986b;Cullen et al, 1989). It has also been proposed that paracrine interactions between stromal tissue and malignant epithelia play an important role in the development and control of human breast cancer (Lippman et al, 1986a;1986b;Cullen et al, 1989).…”

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confidence: 99%

“…It has also been proposed that paracrine interactions between stromal tissue and malignant epithelia play an important role in the development and control of human breast cancer (Lippman et al, 1986a;1986b;Cullen et al, 1989). Human breast cancer cells have been shown to express growth factors for mesenchymal cells (Rozengurt et al, 1985;Peres et al, 1987), suggesting a molecular basis for the generation of tumour stroma.…”

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confidence: 99%

Fibroblast stimulation of breast cancer cell growth in a serum-free system

Ryan

Orr²,

Horgan³

1993

Br J Cancer

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Summary Conditioned media from 14 short term fibroblast cell lines were mitogenic for human breast cancer cells with different steroid receptor profiles in serum-free culture. Fibroblast-conditioned medium stimulated tritiated thymidine incorporation in short term culture and growth in a longer proliferation study as measured by the MTT colourimetric assay.Conditioned media from benign and malignant epithelial cells were non-stimulatory for breast cancer cells but that derived from endothelial cells showed similar stimulation to fibroblasts.Partial purification of fibroblast-conditioned medium identified a peptide with a molecular weight of approximately 8 kDa that showed no affinity for heparin and was mitogenic for MCF-7 breast cancer cells.

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“…Breast tumours express variable levels of receptors for steroids (McGuire et al, 1975;Osborne et al, 1980) and growth factors (Cullen et al, 1989) and it has been proposed that the ligands for these receptors act through a variety of autocrine and paracrine mechanisms. Studies in vivo and in cell culture systems have implicated a number of steroids and polypeptide growth factors (Lippman et al, 1988) but the relative contribution of each growth factor and the precise way in which each acts is not known.…”

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confidence: 99%

Modulation of the proliferative response of breast cancer cells to growth factors by oestrogen

Stewart

Westley²,

May³

1992

Br J Cancer

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SummaryA number of growth factors have been implicated in the control of the proliferation of breast cancer cells and some have been reported to mediate the proliferative effects of oestradiol. MCF-7 cells were treated with growth factors in the presence and absence of oestradiol. Oestradiol increased the response of cells to the proliferative effects of epidermal growth factor (EGF), transforming growth factor alpha (TGF-M) and basic fibroblast growth factor (bFGF). Platelet derived growth factor (PDGF) and cathepsin D had no effect in the presence or absence of oestradiol while TGF-P slightly reduced the stimulation by oestradiol. In the absence of oestradiol, there was little effect of combinations of growth factors although the effects of bFGF and IGF-I were additive. In the presence of oestradiol, the effects of bFGF and TGF-a were additive whereas bFGF acted as an IGF-I antagonist. Overall, bFGF had the greatest effect on cell proliferation although this was less marked than the previously described effect of the IGFs and insulin. (Lippman et al., 1976;Johnson et al., 1989). They therefore provide useful systems for studying the interactions between various growth factors and for understanding the mechanisms involved in the stimulation of proliferation by oestrogens and the interactions between growth factors and steroids.

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Regulation of Human Breast Cancer by Secreted Growth Factors

Cited by 21 publications

References 21 publications

Expression of the FGFR1 gene in human breast‐carcinoma cells

Expression of the FGFR1 gene in human breast‐carcinoma cells

Fibroblast stimulation of breast cancer cell growth in a serum-free system

Modulation of the proliferative response of breast cancer cells to growth factors by oestrogen

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