1994
DOI: 10.1016/s0923-2494(05)80054-9
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Regulation of HIV1 replication by interferon alpha: From laboratory bench to bedside

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Cited by 8 publications
(3 citation statements)
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“…Central nervous system (CNS) HIV infection appears to begin with the transmigration of peripheral HIV-infected cells (eg, monocytes or macrophages) across the blood brain barrier (BBB) ( 38 , 46 , 47 , 53 , 57 , 82 , 89 , 100 , 104 ) and consequently infection, primarily of microglia, the resident macrophages of the brain ( 24 , 32 , 37 , 40 , 50 , 55 , 64 ). Activation of microglia and the release of chemokine, cytokines and neurotoxins in conjunction with secreted HIV protein can damage the brain ( 36 , 56 , 76 , 85 , 103 ).…”
Section: Introductionmentioning
confidence: 99%
“…Central nervous system (CNS) HIV infection appears to begin with the transmigration of peripheral HIV-infected cells (eg, monocytes or macrophages) across the blood brain barrier (BBB) ( 38 , 46 , 47 , 53 , 57 , 82 , 89 , 100 , 104 ) and consequently infection, primarily of microglia, the resident macrophages of the brain ( 24 , 32 , 37 , 40 , 50 , 55 , 64 ). Activation of microglia and the release of chemokine, cytokines and neurotoxins in conjunction with secreted HIV protein can damage the brain ( 36 , 56 , 76 , 85 , 103 ).…”
Section: Introductionmentioning
confidence: 99%
“…Another candidate for immune therapy is IFN-c~, not primarily because of its immune modulatory potential but because of its anti-viral capacities [57]. IFN-c~ is produced in increased amounts during natural HIV-1 infection, and resistance to IFN-c~ of HIV-1 variants was demonstrated in the course of infection.…”
Section: Cytokines and Immune Modulationmentioning
confidence: 99%
“…IFN-c~ is produced in increased amounts during natural HIV-1 infection, and resistance to IFN-c~ of HIV-1 variants was demonstrated in the course of infection. Thus, it was proposed that IFN-c~ therapy would only be useful in early stages of HIV-1 infection [57]. A phase I trial of IFN-c~ in combination with IL-2 showed few side effects and preliminary evidence for immune modulation and anti-viral activity [55].…”
Section: Cytokines and Immune Modulationmentioning
confidence: 99%