Regulation of histone H5 and H1° gene expression under the control of vaccinia virus-specific sequences in interferon-treated chick embryo fibroblasts

Grün, Joachim R.; Redmann-Müller, Ingrid; Blum, Doris; Degen, Hans-Joachim; Doenecke, Detlef; Zentgraf, Hanswalter; Jungwirth, C.

doi:10.1016/0042-6822(91)90067-l

Cited by 4 publications

(1 citation statement)

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“…In addition to erythrocytes and immune cells, other tissues from chickens have been used in biomedical research. For example, the regulation of exogenous histone H5 and H1 0 constructs in chick embryo fibroblasts were exploited in inhibitory studies to test the effect of interferon (IFN) treatment on the expression of immune and histone H1 0 and H5 genes (Grün et al 1991). Studies on the epigenetic regulation of chicken genes with human gene orthologs have been informative in understanding the mechanisms involved in viral infections (e.g., Zika virus) and human diseases to which no cure has yet be discovered (Dodgson and Romanov 2004b;Ambagala et al 2020).…”

Section: Avian Innate Immunitymentioning

confidence: 99%

The chicken model organism for epigenomic research

Beacon

Davie

2021

Genome

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The chicken model organism has advanced the areas of developmental biology, virology, immunology, oncology, epigenetic regulation of gene expression, conservation biology, and genomics of domestication. Further, the chicken model organism has aided in our understanding of human disease. Through the recent advances in high-throughput sequencing and bioinformatic tools, researchers have successfully identified sequences in the chicken genome that have human orthologs, improving mammalian genome annotation. In this review, we highlight the importance of chicken as an animal model in basic and pre-clinical research. We will present the importance of chicken in poultry epigenetics and in genomic studies that trace back to their ancestor, the last link between human and chicken tree of life. There are still many genes of unknown function in the chicken genome yet to be characterized. By taking advantage of recent sequencing technologies, it is possible to gain further insight into the chicken epigenome.

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Section: Avian Innate Immunitymentioning

confidence: 99%