Regulation of Hippo/YAP signaling pathway ameliorates cochlear hair cell injury by regulating ferroptosis

Niu, Xiaorong; Ping, Han; Liu, Junsong; Chen, Zichen; Ma, Xiaoyan; Zhang, Ting; Li, Baiya; Ma, Xudong

doi:10.1016/j.tice.2023.102051

Cited by 2 publications

(2 citation statements)

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“…41 Studies have demonstrated dysregulation of the Hippo signalling pathway in AGA, resulting in the inhibition of hair follicle growth and eventual hair loss. 42,43 Hormonal imbalances, particularly an elevation in dihydrotestosterone (DHT), can activate the Hippo pathway and enhance Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) activity, leading to miniaturization of hair follicles. [44][45][46] This miniaturization leads to shorter, thinner and less pigmented hair strands over time, ultimately culminating in noticeable hair loss.…”

Section: Discussionmentioning

confidence: 99%

“…The Hippo signalling pathway has been implicated in androgenetic alopecia (AGA), a condition characterized by hair loss, commonly known as male pattern baldness or female pattern hair loss 41 . Studies have demonstrated dysregulation of the Hippo signalling pathway in AGA, resulting in the inhibition of hair follicle growth and eventual hair loss 42,43 . Hormonal imbalances, particularly an elevation in dihydrotestosterone (DHT), can activate the Hippo pathway and enhance Yes‐associated protein (YAP)/transcriptional co‐activator with PDZ‐binding motif (TAZ) activity, leading to miniaturization of hair follicles 44–46 .…”

Section: Discussionmentioning

confidence: 99%

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Neurotensin counteracts hair growth inhibition induced by chronic restraint stress

Chen,

Yu,

Guo

et al. 2023

Experimental Dermatology

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Stress has been considered as a potential trigger for hair loss through the neuroendocrine‐hair follicle (HF) axis. Neurotensin (NTS), a neuropeptide, is known to be dysregulated in the inflammatory‐associated skin diseases. However, the precise role of NTS in stress‐induced hair loss is unclear. To investigate the function and potential mechanisms of NTS in stress‐induced hair growth inhibition, we initially detected the expression of neurotensin receptor (Ntsr) and NTS in the skin tissues of stressed mice by RNA‐sequencing and ELISA. We found chronic restraint stress (CRS) significantly decreased the expression of both NTS and Ntsr in the skin tissues of mice. Intracutaneous injection of NTS effectively counteracted CRS‐induced inhibition of hair growth in mice. Furthermore, NTS regulated a total of 1093 genes expression in human dermal papilla cells (HDPC), with 591 genes being up‐regulated and 502 genes being down‐regulated. GO analysis showed DNA replication, cell cycle, integral component of plasma membrane and angiogenesis‐associated genes were significantly regulated by NTS. KEGG enrichment demonstrated that NTS also regulated genes related to the Hippo signalling pathway, axon guidance, cytokine–cytokine receptor interaction and Wnt signalling pathway in HDPC. Our results not only uncovered the potential effects of NTS on stress‐induced hair growth inhibition but also provided an understanding of the mechanisms at the gene transcriptional level.

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