Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory

Siddiqui, Sarfraj Ahmad; Singh, Sanjay; Ugale, Rajesh R.; Ranjan, Vandana; Kanojia, Rohit; Saha, Sudipta; Tripathy, Sukanya; Kumar, Shailendra; Mehrotra, Santosh; Modi, Dinesh Raj; Prakash, Anand

doi:10.1016/j.brainresbull.2019.05.011

Cited by 12 publications

(10 citation statements)

References 71 publications

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“…There is a significant body of evidence pointing to the important role of HDACs in the regulation of gene expression in the brain (Van Dyke, 2014). Importantly, HDAC1 has been shown to play a role in the consolidation and extinction of fear memory (Siddiqui et al, 2019). Adler and Schmauss (2016) showed that decreasing association of HDAC1 with the promoters of plasticity-associated genes increased the expression of these genes and induced cognitive deficits triggered by early life stress.…”

Section: Activity-dependent Chromatin Reorganization In Neuronsmentioning

confidence: 99%

Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

et al. 2022

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Section: Activity-dependent Chromatin Reorganization In Neuronsmentioning

confidence: 99%

Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

et al. 2022

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“…In contrast, there were no effects of temporary IL inactivation with muscimol on inhibitory avoidance memory consolidation 17 . Studies focusing on cued or contextual fear memory consolidation have also reported changes in the IL, including depressed intrinsic neuronal excitability 18 , 19 and increased Arc expression 20 , but not c-fos induction or histone acetylation 21 , 22 . Post-acquisition gamma irradiation potentiated the consolidation of a contextual fear memory trace, an effect associated with reduced IL neuronal activation 23 .…”

Section: Introductionmentioning

confidence: 99%

Infralimbic cortex controls fear memory generalization and susceptibility to extinction during consolidation

Bayer

Bertoglio

2020

Sci Rep

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Lesioning or inactivating the infralimbic (IL) subregion of the medial prefrontal cortex before acquisition produces more generalized and extinction-resistant fear memories. However, whether and how it modulates memory specificity and extinction susceptibility while consolidation takes place is still unknown. The present study aims to investigate these questions using muscimol-induced temporary inactivation and anisomycin-induced protein synthesis inhibition in the rat IL following contextual fear conditioning. Results indicate that the IL activity immediately after acquisition, but not six hours later, controls memory generalization over a week, regardless of its strength. Such IL function depends on the context-shock pairing since muscimol induced no changes in animals exposed to immediate shocks or the conditioning context only. Animals in which the IL was inactivated during consolidation extinguished similarly to controls within the session but were unable to recall the extinction memory the following day. Noteworthy, these post-acquisition IL inactivation-induced effects were not associated with changes in anxiety, as assessed in the elevated plus-maze test. Anisomycin results indicate that the IL protein synthesis during consolidation contributes more to producing extinction-sensitive fear memories than memory specificity. Collectively, present results provide evidence for the IL's role in controlling generalization and susceptibility to extinction during fear memory consolidation.

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“…Hdac2 plays a key role in epigenetically regulating gene expression by catalyzing the removal of the acetyl group from histone proteins on DNA, and dysregulation of Hdac2 has been reported in fear memory consolidation and its extinction. Downregulated expression of Hdac2 is observed in fear memory in male rats (Siddiqui et al, 2019) and is involved in the effects of early life stress (Burenkova, Aleksandrova, & Zarayskaya, 2019) and emotional disorders (Jamal et al, 2017). SCVS but not CUMS significantly decreased expression of HDAC2 in male hippocampus only.…”

Section: Discussionmentioning

confidence: 99%

Sex difference in depression: Which animal models mimic it.

Iqbal

Adu-Nti

Wang

et al. 2020

Behavioral Neuroscience

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affects both women and men, but women are 2 times more susceptible to the incidence of depression. Although a number of studies report sex differences in stress responses, it remains unclear which animal models of depression can better mimic the sex difference in human depression. The majority of stress models used male rodents whereas fewer studies included females. The aims of this study were to determine which rat stress models mimic the sex difference in depression and to identify sex-specific risk factors for depression model-induced depression-like behaviors. Here, we compared subchronic variable stress (SCVS) and chronic unpredictable mild stress (CUMS) models to evaluate the susceptibility versus resilient phenotypes in male and female rats. SCVS induced depression-like behaviors in female rats only. The CUMS paradigm was more likely to induce depression-like behaviors in male rats. Furthermore, to explore the underlying mechanisms, we used quantitative reverse transcriptase polymerase chain reaction to examine and compare the messenger RNA (mRNA) levels of various transcripts previously shown to be involved in psychiatric disorders in RNA-sequencing/microarray studies including serotonin receptor-7, early growth response-2, histone deacetylase-2, roundabout guidance receptor-2 (Robo2), serum/glucocorticoid regulated kinase-2, orthodenticle homeobox-2, parathyroid hormone-2 receptor, and neuronal PAS domain protein-4 in the hippocampus after exposure of rats to SCVS and CUMS. Our results showed that SCVS significantly altered the mRNA levels of neuronal PAS domain protein-4, orthodenticle homeobox-2, Robo2, parathyroid hormone-2 receptor, and serum/glucocorticoid regulated kinase-2 in the female hippocampus only, and histone deacetylase-2 in only the male hippocampus. CUMS significantly changed the mRNA levels of one transcript (Robo2) in the female hippocampus only when compared with SCVS. Overall, this study shows that SCVS can be used to study sex differences in depression-like behaviors in rats.

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Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory

Cited by 12 publications

References 71 publications

Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

Infralimbic cortex controls fear memory generalization and susceptibility to extinction during consolidation

Sex difference in depression: Which animal models mimic it.

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