Regulation of haptoglobin secretion by recombinant bovine cytokines in primary cultured bovine hepatocytes

Yoshioka, Miyako; Watanabe, Atsushi; Shimada, Nobuaki; Murata, Hideo; Yokomizo, Yuichi; Nakajima, Yasuyuki

doi:10.1016/s0739-7240(02)00174-1

Cited by 52 publications

(41 citation statements)

References 22 publications

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“…Of the proinflammatory cytokines, tumour necrosis factor-alpha (TNF-α) is one of the major mediators of APP synthesis in the liver (Alsemgeest et al1996;Yoshioka et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Selected serum biochemical parameters and acute phase protein levels in a herd of Saanen goats showing signs of pregnancy toxaemia

Albay¹,

Karakurum²,

Şahinduran³

et al. 2014

Vet. Med. - Czech

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ABSTRACT:The purpose of this study was to examine selected serum biochemical parameters and acute phase protein levels in a herd of Saanen goats showing signs of pregnancy toxaemia. Seventy five female goats were used and divided into three groups. Group 1 (n = 57) (blood serum glucose levels were within the physiological range), Group 2 (n = 11) (serum glucose values were low) and Group 3 (n = 7) (serum glucose values were high). Goats in Groups 2 and 3 were diagnosed with pregnancy toxaemia. Apart from serum glucose, β-hydroxybutyrate (BHB), triglycerides, blood pH, calcium (Ca), sodium (Na), potassium (K), aspartate aminotransferase (AST), alanine aminotransferase (ALT), haptoglobin (Hp), serum amyloid A (SAA) and tumour necrosis factor-α (TNF-α) were measured in all animals. In Group 3 average Hp and SAA values were found to be significantly (P < 0.001) higher than in Groups 1 and 2, and also higher in Group 2 than in Group 1. Acute phase proteins in goats with pregnancy toxaemia may be used in the course and the prognosis of the disease. The evaluation of acute phase proteins is useful and also quicker in cases of suspected pregnancy intoxication.

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“…Of the proinflammatory cytokines, tumour necrosis factor-alpha (TNF-α) is one of the major mediators of APP synthesis in the liver (Alsemgeest et al1996;Yoshioka et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Selected serum biochemical parameters and acute phase protein levels in a herd of Saanen goats showing signs of pregnancy toxaemia

Albay¹,

Karakurum²,

Şahinduran³

et al. 2014

Vet. Med. - Czech

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“…During the APR, the serum concentration of the acute phase proteins (APP) changes dramatically [9][10][11][12] . These proteins are synthesized mainly in the liver.…”

Section: Introductionmentioning

confidence: 99%

“…These proteins are synthesized mainly in the liver. The secretion of APPs is regulated by proinflamatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α, and IL-1β 10,12 . Serum haptoglobin (Hp) and serum amyloid-A (SAA) are the major APP in cattle [10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

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Acute Phase Proteins, Clinical, Hematological and Biochemical Parameters in Dairy Cows Naturally Infected with Anaplasma Marginale

Coşkun¹,

Ekici²,

Güzelbekteş³

et al. 2012

Kafkas Univ Vet Fak Derg

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SummaryThe aim of the study was to evaluate acute phase response via Haptoglobin and serum amyloid-A concentrations in dairy cows naturally infected with Anaplasma marginale. The second aim of the study was to determine the changes in clinical, hematological and biochemical parameters in dairy cows naturally infected Anaplasma marginale. A total of 40 dairy cattle suffering from bovine anaplasmosis were included to the study from a dairy cattle herd. A total of 10 healthy dairy cattle were selected for control group. Analysis of acute phase proteins, hematologic analysis and biochemical analysis was performed in this study. Serum haptoglobin and serum amyloid-A concentrations significantly increased in cattle infected with Anaplasma marginale compared to healthy cattle. All cattle in infected group demonstrated clinical signs of anaplasmosis. Significantly decreased red blood cell count, packed cell volume, and hemoglobin concentration were observed in infected cattle compared to the control group. Serum aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin concentrations were significantly increased in infected cattle compared with the control group. In conclusion, the changes of biochemical and hematological parameters may be indicate of anemia and tissue damage in cattle with anaplasmosis. Serum haptoglobin and serum amyloid-A concentrations could be usefull in evaluate of acute phase response in cattle infected with Anaplasma marginale.

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“…One of the mechanisms involved is the production and secretion of acute-phase proteins (APPs) by the liver (Eckersall and Conner, 1988). This is effected by pro-inflammatory cytokines (IL-1, IL-6, TNF-α), regardless of the inflammation-causing factor (Godson et al, 1995;Alsemgeest et al, 1996;Yoshioka et al, 2002). With the aid of this nonspecific reaction it is possible to use changes in the concentrations of APPs universally to monitor the course of the disease, independently of its nature (Jawor and Stefaniak, 2006).…”

mentioning

confidence: 99%

Determination of selected acute phase proteins during the treatment of limb diseases in dairy cows

Jawor¹,

Steiner²,

Stefaniak³

et al. 2008

Vet. Med. - Czech

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ABSTRACT:The purpose of this study was to assess the diagnostic value of fibrinogen, haptoglobin, and serum amyloid A determination in the monitoring of the treatment of limb diseases in dairy cows. Fourteen lame cows were examined, while 10 clinically healthy cows constituted the control group. Blood samples from the ill animals were collected on three occasions: (1) upon arrival at the clinic, (2) between the third and sixth day after arriving, and (3) upon return to the owner. Blood samples from the control cows were collected once. Plasma levels of fibrinogen, haptoglobin, serum amyloid A, and total serum protein and its fractions (albumin, α-, β-, γ-globulins) were measured. Significantly higher fibrinogen, haptoglobin, and serum amyloid A levels were observed in the affected cows upon arrival at the clinic than in the control cows. Based on the changes in fibrinogen, haptoglobin, and serum amyloid A concentrations, the cows were divided into those with a systematic decrease in acute-phase protein levels during treatment (Group I, n = 6) and those which showed an increase in one or more acute-phase proteins despite treatment (Group II, n = 8). A stepwise decrease in the examined acute-phase proteins was observed in the first group and indicated an uncomplicated course of treatment; however, treatment of the second group did not appear to be wholly successful. A majority of the cows under treatment (n = 13) exhibited abnormal levels of the examined acute-phase proteins upon return to the owner. This indicates that these patients did not recover completely. The monitoring of plasma acute-phase protein concentrations can be a valuable complement to the clinical assessment of the treatment course and in the early detection of disease complications.

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Regulation of haptoglobin secretion by recombinant bovine cytokines in primary cultured bovine hepatocytes

Cited by 52 publications

References 22 publications

Selected serum biochemical parameters and acute phase protein levels in a herd of Saanen goats showing signs of pregnancy toxaemia

Selected serum biochemical parameters and acute phase protein levels in a herd of Saanen goats showing signs of pregnancy toxaemia

Acute Phase Proteins, Clinical, Hematological and Biochemical Parameters in Dairy Cows Naturally Infected with Anaplasma Marginale

Determination of selected acute phase proteins during the treatment of limb diseases in dairy cows

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