Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice

Zhu, Lin; Cheng, Ya; Hu, Baifei; Xia, Hui; Bian, Qinglai; Liu, Yang; Kong, Mei; Zhou, Shuhan; Liu, Hongtao

doi:10.1016/j.jnutbio.2022.109019

Cited by 29 publications

(15 citation statements)

References 51 publications

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“…[36][37][38] In previous studies, PCPs had been degraded into PCOs, and it was proved that PCOs could act as a prebiotic to treat glucolipid disorders by reshaping the structure of intestinal bacteria. 26,39 In this study, we further examined the protective effect of PCOs on colitis. The results showed that PCOs could prevent the occurrence of colitis by targeting the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

et al. 2023

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“…In addition, the effective component of Poria cocos polysaccharide that changes its chemical structure through hydroxymethylation β-(1-3) -D-glucan and its carboxymethyl derivatives can improve the ability to bind bile acid [51][52][53][54], inhibit the reabsorption of bile acid and increase its excretion. We also found that the sub oligosaccharide (PCO) from Poria cocos can significantly reduce the expression of lipid related metabolic genes and gluconeogenesis related genes, increase the expression of bile acid synthase, and increase the content of cholic acid and ursodeoxycholic acid [55] (Table 2.)…”

Section: Bile Acid Metabolismmentioning

confidence: 82%

“…In addition, Poria cocos polysaccharide can also increase the level of intestinal bifidobacteria, increase the flora producing butyrate, thereby increasing the intestinal butyrate production [68], increase the species richness and diversity. In the model mice treated with PCO, the ruminal coccidae and anaerobic plasma bacteria were down regulated, but the abundance of lactobacilli and Riemannia bacteria were up regulated [55].…”

Section: Iron Deathmentioning

confidence: 94%

Research Progress on the Mechanism of Action of Danggui-Shaoyao-San Polysaccharide on Some Complications of Type II Diabetes Mellitus: A Review

Yuan¹,

Fu²,

Yu³

2022

Asian J Complement Altern Med

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Type II diabetes mellitus (T2DM) is a group of metabolic diseases characterized by hyperglycemia, and it will cause a variety of complications. Through the research on Danggui-Shaoyao-San (DSS), scholars found that it has an active role in the treatment of diabetes and some complications. Danggui-Shaoyao-San polysaccharide (P-DSS) is the main component of Danggui-Shaoyao-San. P-DSS can participate in the physiological regulation of oxidative stress, anti-inflammatory, glucose and lipid metabolism, endoplasmic reticulum stress, bile acid metabolism and iron metabolism, especially bile acid can effectively regulate the disorder of glucose and lipid metabolism in the body, which provides a new idea for the treatment of diabetes. In addition, the therapeutic effect of P-DSS on diabetic complications may also be related to cell autophagy and intestinal flora, but there is little systematic analysis on the mechanism of P-DSS in treating diabetes and its complications. Therefore, this article reviews the potential mechanism of P-DSS in treating diabetes and its complications in detail, providing a reasonable theoretical basis for further research on P-DSS in treating T2DM.

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“…( 34 ). Poria cocos oligosaccharides could improve disorders of glucolipid metabolism by regulating intestinal flora ( 35 ). Salvia miltiorrhiza Polysaccharide combined with probiotics can improve insulin resistance and NAFLD via modulating intestinal flora ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial

et al. 2023

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ObjectiveAs a metabolic disease, one important feature of non-alcoholic fatty liver disease (NAFLD) is the disturbance of the intestinal flora. Spleen-strengthening and liver-draining formula (SLF) is a formula formed according to the theory of “One Qi Circulation” (Qing Dynasty, 1749) of Traditional Chinese Medicine (TCM), which has shown significant therapeutic effect in patients with NAFLD in a preliminary clinical observation. In this study, we aim to explore the mechanism of SLF against NAFLD, especially its effect on glucolipid metabolism, from the perspective of intestinal flora.MethodsA prospective, randomized, controlled clinical study was designed to observe the efficacy and safety of SLF in the treatment of NAFLD. The study participants were randomly and evenly divided into control group and treatment group (SLF group). The control group made lifestyle adjustments, while the SLF group was treated with SLF on top of the control group. Both groups were participated in the study for 12 consecutive weeks. Furthermore, the feces of the two groups were collected before and after treatment. The intestinal flora of each group and healthy control (HC) were detected utilizing 16S rRNA gene sequencing.ResultsCompared with the control group, the SLF group showed significant improvements in liver function, controlled attenuation parameter (CAP), and liver stiffness measurement (LSM), meanwhile, patients had significantly lower lipid and homeostasis model assessment of insulin resistance (HOMA-IR) with better security. Intestinal flora 16S rRNA gene sequencing results indicated reduced flora diversity and altered species abundance in patients with NAFLD. At the phylum level, Desulfobacterota levels were reduced. Although Firmicutes and Bacteroidetes did not differ significantly between HC and NAFLD, when grouped by alanine transaminase (ALT) and aspartate transaminase (AST) levels in NAFLD, Firmicutes levels were significantly higher in patients with ALT or AST abnormalities, while Bacteroidetes was significantly lower. Clinical correlation analysis showed that Firmicutes positively correlated with gender, age, ALT, AST, LSM, and Fibroscan-AST (FAST) score, while the opposite was true for Bacteroidetes. At the genus level, the levels of Alistipes, Bilophila, Butyricimonas, Coprococcus, Lachnospiraceae_NK4A136 group Phascolarctobacterium, Ruminococcus, UCG-002, and UCG-003 were reduced, whereas abundance of Tyzzerella increased. There was no statistically significant difference in Firmicutes and Bacteroidota levels in the SLF group before and after treatment, but both bacteria tended to retrace. At the genus level, Coprococcus (Lachnospiraceae family), Lachnospiraceae_NK4A136 group (Lachnospiraceae family), and Ruminococcus (Ruminococcaceae family) were significantly higher in the SLF group after treatment, and there was also a tendency for Bilophila (Desulfovibrionaceae family) to be back-regulated toward HC.ConclusionsSLF can improve liver function and glucolipid metabolism in patients with NAFLD and lower down liver fat content to some extent. SLF could be carried out by regulating the disturbance of intestinal flora, especially Coprococcus, Lachnospiraceae_NK4A136 group, and Ruminococcus genus.

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Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice

Cited by 29 publications

References 51 publications

Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

Research Progress on the Mechanism of Action of Danggui-Shaoyao-San Polysaccharide on Some Complications of Type II Diabetes Mellitus: A Review

The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial

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