“…Increased expression of FUT1 and FUT2 genes, which encode enzymes that catalyze the linkage between fucose and its acceptor protein through an α1-2 linkage, accounts for elevated fucosylation although other regulatory steps are likely to contribute as well [25, 30, 32, 34, 43, 44]. These findings contrast with previous studies in murine PSCs where α1-2 fucosylation is not prevalent, highlighting potential differences in glycosylation patterns between the two species [13, 33]. Alternatively, rather than being indicative of differences at the species level this apparent conflict may indicate that ‘naive’ (murine ESCs) and ‘primed’ PSCs (human ESCs) have a different cell surface glycome, consistent with the earlier work of Nash and co-workers [29].…”