Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Guan, Dandan; Zhao, Lidan; Chen, Shuai; Yu, Bing; Yu, Jie

doi:10.1186/s12967-016-0821-0

Cited by 30 publications

(19 citation statements)

References 71 publications

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“…FGF receptors consist of three extracellular immunoglobulin (Ig)-like domains and single transmembrane domain. Four FGF receptors, that is, FGFR-1 through FGFR-4, have been identified [2][3][4]. In order for the FGF to bind with its receptor, proteoglycans, such as heparin or heparin sulfate, are required to protect FGF from degradation and create a local reservoir of FGF.…”

Section: Introductionmentioning

confidence: 99%

“…FGF15/19 and FGF21 are key members of the FGF19 subfamily. Due to the absence of a heparin binding domain, both FGF19 and FGF21 are secreted into the bloodstream and function as an endocrine factor that regulate glucose/lipid metabolism and energy homeostasis in multiple target organs, including the liver, heart, skeletal muscle, testis, kidney, blood vessel, and pancreas [4][5][6]. FGF19 and FGF21 require specific membrane-bound cofactors, α-Klotho and β-Klotho, for FGFR binding and activation.…”

Section: Introductionmentioning

confidence: 99%

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An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

et al. 2018

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Fibroblast growth factors (FGFs) are responsible for the regulation of a wide range of biological functions, among which cellular proliferation, survival, migration, and differentiation could be pointed out. FGF19 controls the enterohepatic bile acid/cholesterol system, and FGF21 modulates fatty acid/glucose metabolism. Obesity, type 2 diabetes, coronary artery disease, and cancer, all can alter FGF21 circulating concentrations. In contrast to FGF21, metabolic diseases exhibit reduced serum FGF19 levels. Accordingly, FGF19 and FGF21 play important roles in regulating glucose and lipid metabolism. Hence, we present here a timely review on the relationship between FGF19/21 and metabolic diseases, especially obesity, and their probable role in development and treatment of obesity seems necessary.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

et al. 2018

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“…*P < 0.05, **P < 0.01 and ***P < 0.001 by one-way ANOVA with unpaired two-tailed Student's t test fasting increased Fgf21 mRNA expression level in female soleus muscle and increased FGF21 level in plasma in both female and male mice. Emerging evidence has shown that fasting increases hepatic Fgf21 mRNA expression and plasma FGF21 level in mice [47]. FGF21 plays a role in fasting-induced muscle atrophy and weakness.…”

Section: Discussionmentioning

confidence: 97%

“…FGF15/19 induced skeletal muscle hypertrophy and blocked muscle atrophy [20]. FGF15/19 is mainly secreted from the small intestine in response to feed [47]. FGF21 has been reported negatively to regulate muscle mass and contribute towards skeletal muscle atrophy [16].…”

Section: Discussionmentioning

confidence: 99%

Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice

et al. 2020

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Fibroblast growth factors (FGFs) belong to a large family comprising 22 FGF polypeptides that are widely expressed in tissues. Most of the FGFs can be secreted and involved in the regulation of skeletal muscle function and structure. However, the role of fasting on FGF expression pattern in skeletal muscles remains unknown. In this study, we combined bioinformatics analysis and in vivo studies to explore the effect of 24-h fasting on the expression of Fgfs in slow-twitch soleus and fast-twitch tibialis anterior (TA) muscle from male and female C57BL/6 mice. We found that fasting significantly affected the expression of many Fgfs in mouse skeletal muscle. Furthermore, skeletal muscle fibre type and sex also influenced Fgf expression and response to fasting. We observed that in both male and female mice fasting reduced Fgf6 and Fgf11 in the TA muscle rather than the soleus. Moreover, fasting reduced Fgf8 expression in the soleus and TA muscles in female mice rather than in male mice. Fasting also increased Fgf21 expression in female soleus muscle and female and male plasma. Fasting reduced Fgf2 and Fgf18 expression levels without fibre-type and sex-dependent effects in mice. We further found that fasting decreased the expression of an FGF activation marker gene-Flrt2 in the TA muscle but not in the soleus muscle in both male and female mice. This study revealed the expression profile of Fgfs in different skeletal muscle fibre types and different sexes and provides clues to the interaction between the skeletal muscle and other organs, which deserves future investigations.

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“…Unlike most other members of the family, FGF19 lacks conventional heparin‐binding domain, which allows it to diffuse beyond its site of origin and thus act as endocrine hormones. In addition to promoting GB refilling, FGF19 is thought to favourably regulate lipid metabolism, glucose homeostasis, and energy expenditure via complex pathways, whose details are beyond the scope of the present review . Interestingly, the serum level of FGF19 also fluctuates daily with obvious peaks occurring 90 to 120 minutes following the postprandial rise in serum BA .…”

Section: Gb In Systemic Metabolic Regulationmentioning

confidence: 95%

Gall bladder: The metabolic orchestrator

Tian

Chen

2019

Diabetes Metabolism Res

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It is commonly held that the gall bladder (GB) is not indispensable for life. However, recent studies strongly suggest that GB removal can lead to the development of metabolic syndrome (MetS). With the recent recognition of the role of bile acids (BAs) in systemic metabolic regulation, it is worthwhile to re-examine the function of the GB, which can be regarded as the physiological "pacemaker" of BA flow. Thus, in the present study, we review the role of the GB in BA flow regulation, describe the epidemiologic evidence that associates cholecystectomy with various components of MetS, and discuss the possible mechanism behind these connections in order to demonstrate the pivotal role that GB plays in metabolic regulation.

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Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Cited by 30 publications

References 71 publications

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice

Gall bladder: The metabolic orchestrator

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