Regulation of FGF soluble receptor type 1 (SR1) expression and distribution in developing, degenerating, and FGF2-treated retina

Guillonneau, Xavier; Régnier‐Ricard, Fabienne; Jeanny, Jean‐Claude; Thomasseau, Sylvie; Courtois, Yves; Mascarelli, Frédéric

doi:10.1002/(sici)1097-0177(200001)217:1<24::aid-dvdy3>3.0.co;2-c

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…FGFR1 lacking its transmembrane domain can be released and competes with membrane FGFR for the extracellular ligand (Guillonneau et al, 1998(Guillonneau et al, , 2000Wang et al, 2000). In BAMCs maintained in control serum-free medium transfected FGFR1(TMϪ) had only a minimal effect (one-third of the wild-type FGFR1 effect) on FGF-2 promoter activity ( Figure 3C).…”

Section: Resultsmentioning

confidence: 99%

Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors

Moffett

Myers

et al. 2001

MBoC

198

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In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

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Section: Resultsmentioning

confidence: 99%

Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors

Moffett

Myers

et al. 2001

MBoC

198

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“…In addition, exogenous FGF1 was also detected associated with the extracellular matrix of the retina in the absence of any RPE proliferative pathology (Mascarelli et al, 1989), showing that exogenous FGF1 is not always associated with cell proliferation. This could be due to the trapping of exogenous FGF1 by FGF-binding proteins like the soluble form of FGFR and HSPG (Guillonneau et al, 2000). Another possibility is that endogenous FGF1 may activate by an intracrine mode of action, retinal cell proliferation under particular conditions like oxidative stress and nutriment deprivation.…”

Section: Discussionmentioning

confidence: 99%

Regulation of proliferation-survival decisions is controlled by FGF1 secretion in retinal pigmented epithelial cells

et al. 2000

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Fibroblast growth factor 1 (FGF1) induces proliferation and dierentiation in a wide variety of cells of mesodermal and neuroectodermal origin. FGF1 has nò classical' signal sequence to direct its secretion, and there has been considerable debate concerning FGF1 secretion and its role in the biological activities of FGF1. We investigated the eects of FGF1 secretion and the signalling induced by signal peptide (SP)-containing FGF1 and SP-less FGF1, on the proliferation and the apoptosis in retinal pigmented epithelial (RPE) cells. Primary RPE cell cultures were transfected with FGF1 (FGF1 cells) and SP-FGF1 (SP-FGF1 cells) cDNAs. SP-FGF1 cells secreted large amount of FGF1 and actively proliferated, whereas FGF1 and control cells did not. Secreted FGF1 induced short-term activation of both FGFR1 and ERK2, which were required for cell proliferation. In contrast, SP-FGF1 cells stopped secreting FGF1 and died rapidly, if cultured in the absence of serum. Surprisingly, FGF1 cells, but not control cells, secreted FGF1 and were resistant to apoptosis induced by serum depletion. Secreted FGF1 induced long-term activation of FGFR1 and ERK2, which was necessary to induce a constant and high level of Bcl-x production, and to induce cell survival in FGF1 cells. Downregulation of ERK2 and Bcl-x increased apoptosis. Thus, the proliferation and survival activities of FGF1 depend on the secretion of FGF1 which is determined by the cell culture conditions. Cell proliferation was SP-dependent, whereas cell survival was not. The signal peptide controls the level and duration, whispering or shouting', of ERK2 activation cells which determines FGF1 biological function and may have important implications for anti-degenerative and antiproliferative treatments. Oncogene (2000) 19, 4917 ± 4929.

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“…62:40 -55, 2000. The presence of FGFs (FGF-1 and FGF-2) in the brain and their neurite-promoting effect on various cells suggest that these factors have important physiological functions in the nervous system (Gospodarowicz, 1987;Ernfors et al, 1990;Matsuyama et al, 1992;GomezPinilla et al, 1994). In vitro, FGF-1 and FGF-2 have been shown to influence proliferation and differentiation and to support neuron survival and neuritic growth (Morrison et al, 1986;Walicke et al, 1986Walicke et al, , 1988Unsicker et al, 1987;Zhao and Barnstable, 1996;Guillonneau et al, 2000).…”

mentioning

confidence: 99%

Fibroblast growth factors (FGF-1, FGF-2) promote migration and neurite growth of mouse cochlear ganglion cells in vitro: Immunohistochemistry and antibody perturbation

Hossain

Morest

2000

J. Neurosci. Res.

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Regulation of FGF soluble receptor type 1 (SR1) expression and distribution in developing, degenerating, and FGF2-treated retina

Cited by 4 publications

References 52 publications

Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors

Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors

Regulation of proliferation-survival decisions is controlled by FGF1 secretion in retinal pigmented epithelial cells

Fibroblast growth factors (FGF-1, FGF-2) promote migration and neurite growth of mouse cochlear ganglion cells in vitro: Immunohistochemistry and antibody perturbation

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