Regulation of fatty acid delivery to metastases by tumor endothelium
Deanna N. Edwards,
Shan Wang,
Wenqiang Song
et al.
Abstract:Tumor metastasis, the main cause of death in cancer patients, requires outgrowth of tumor cells after their dissemination and residence in microscopic niches. Nutrient sufficiency is a determinant of such outgrowth. Fatty acids (FA) can be metabolized by cancer cells for their energetic and anabolic needs but impair the cytotoxicity of T cells in the tumor microenvironment (TME), thereby supporting metastatic progression. However, despite the important role of FA in metastatic outgrowth, the regulation of intr… Show more
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