Regulation of Expression of Secretory Leukocyte Protease Inhibitor by Progesterone in BeWo Choriocarcinoma Cells

Sidharthan, Neelima P.; Rao, A Jagannadha

doi:10.4172/2157-7536.1000107

Cited by 2 publications

(1 citation statement)

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“…They are the key regulators of numerous biological pathways that initiate inflammation, coagulation, angiogenesis, apoptosis, and complement activation; and are associated with cell survival, development, repairs, and host defense at the sites of infection and inflammation [ 10 , 11 ].Progesterone increases secretory leukocyte protease inhibitor (SLPI), a serpin secreted by the human nasal epithelial cells and saliva. This is an important respiratory tract host defense protein which confers local protection against microbial, fungal, and viral infections [ 12 , 13 ]. Increase of SLPI by progesterone also contributes to the confinement of inflammation and tissue damage, thereby facilitating wound healing.…”

Section: Resultsmentioning

confidence: 99%

COVID-19 and Progesterone: Part 1. SARS-CoV-2, Progesterone and its potential clinical use

Shah

2021

Endocrine and Metabolic Science

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SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection is a global medical challenge. Experience based medicines and therapies are being attempted and vaccines are beingdeveloped. SARS-CoV-2 infection exhibits varied patterns of infection and clinical presentations with varied disease outcomes. These attributes are strongly suggestive of some variables that vary among individuals and that affect the course of SARS-CoV-2 infection and symptoms of COVID-19 (Corona Virus Disease of 2019). Sex hormones vary with ageing, between the sexes, among individuals and populations. Sex hormones are known to play a role in immunity and infections. Progesterone is a critical host factor to promote faster recovery following Influenza A virus infection. Anti-inflammatory effects of progesterone are noted.In part 1 of the current study the regulatory role ofprogesterone for SARS-CoV-2 infection and COVID-19 is analyzed. The role of progesterone at different stages of the SARS CoV-2 infection is investigated with respect to two types of immunity status: immune regulation and immune dysregulation.Progesterone could have various alleviating impacts from SARS-CoV-2 entry till recovery: reversing of hypoxia, stabilizing of blood pressure, controlling thrombosis, balancing electrolytes, reducing the viral load, regulation of immune responses, damage repair, and clearance of debris among others. The present research adds to the available evidence by providing a comprehensive and thorough evaluation ofthe regulatory role of progesterone in SARS COV-2 infection, COVID-19 pathogenesis, and immune dysregulation. The available evidencehas implications for upcoming studies about pathophysiology of COVID-19, as well as the roles of progesterone and other hormones in other infectious diseases.

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Section: Resultsmentioning

confidence: 99%