Regulation of estrogen sulfotransferase (SULT1E1) expression by proliferation state in MCF10A human breast epithelial cells: Potential role of microRNAs
Abstract:The MCF10A cell line represents a model of the normal human breast epithelial cell. Estrogen sulfotransferase (SULT1E1), a major estrogen‐inactivating enzyme, is up‐regulated in confluent relative to preconfluent MCF10A cells. The mechanism responsible for SULT1E1 up‐regulation in confluent MCF10A cells was investigated. Transient or stable tranfection of reporter constructs containing up to 7 kb of the SULT1E1 5′‐flanking region failed to recapitulate confluency‐induced SULT1E1 up‐regulation. The half‐life of… Show more
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