Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA

Fan, Alex Xiu‐Cheng; Hossain, Md. Abul; Stees, Jared; Gavrilova, E. V.; Bungert, Jörg

doi:10.1016/b978-0-12-799958-6.00011-1

Cited by 4 publications

(5 citation statements)

References 111 publications

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“…Further work is therefore required to demonstrate the affinity of such transcription factors for methylated binding sequences at the putative cichlid locus control regions and their association with increased Hb transcription, which is currently unknown in cichlids. Finally, the hematopoietic transcription factor gene Scl/Tal1, a major actor in red blood cell differentiation 29,32 , whose sequence recognition binding motif is highly enriched in DMR sequences (Extended Data Fig. 5b), is also expressed in benthic fish only (FDR < 0.013; Extended Data Fig.…”

Section: Articlementioning

confidence: 99%

Epigenetic divergence during early stages of speciation in an African crater lake cichlid fish

et al. 2022

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Epigenetic variation can alter transcription and promote phenotypic divergence between populations facing different environmental challenges. Here, we assess the epigenetic basis of diversification during the early stages of speciation. Specifically, we focus on the extent and functional relevance of DNA methylome divergence in the very young radiation of Astatotilapia calliptera in crater Lake Masoko, southern Tanzania. Our study focuses on two lake ecomorphs that diverged approximately 1,000 years ago and a population in the nearby river from which they separated approximately 10,000 years ago. The two lake ecomorphs show no fixed genetic differentiation, yet are characterized by different morphologies, depth preferences and diets. We report extensive genome-wide methylome divergence between the two lake ecomorphs, and between the lake and river populations, linked to key biological processes and associated with altered transcriptional activity of ecologically relevant genes. Such genes differing between lake ecomorphs include those involved in steroid metabolism, hemoglobin composition and erythropoiesis, consistent with their divergent habitat occupancy. Using a common-garden experiment, we found that global methylation profiles are often rapidly remodeled across generations but ecomorph-specific differences can be inherited. Collectively, our study suggests an epigenetic contribution to the early stages of vertebrate speciation.

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Section: Articlementioning

confidence: 99%

Epigenetic divergence during early stages of speciation in an African crater lake cichlid fish

et al. 2022

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“…Individual globin subunit forms a dimer with the unlike globin chain through two distinct interfaces, high-affinity α1β1 and low-affinity α1β2 [117]. Heme is a critical component of Hb which reversibly binds O 2 through reduced state iron (Fe 2+ ), located within a hydrophobic pocket on the external surface of the protein [124]. Oxidized (Fe 3+ ) heme cannot bind O 2 and is relatively unstable.…”

Section: Regulation At the Protein Level Hemoglobin Structure And Function Modulationmentioning

confidence: 99%

“…Besides previously described regulation by oxygen sensing and EPO signaling, erythropoiesis is tightly controlled also by several other hormones and pathways directly or indirectly involved in erythrocyte maturation and degradation [124,125,137].…”

Section: Regulation Of Red Blood Cells Production and Degradationmentioning

confidence: 99%

Molecular Pathways Involved in the Development of Congenital Erythrocytosis

Tomc

Debeljak

2021

Genes

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Patients with idiopathic erythrocytosis are directed to targeted genetic testing including nine genes involved in oxygen sensing pathway in kidneys, erythropoietin signal transduction in pre-erythrocytes and hemoglobin-oxygen affinity regulation in mature erythrocytes. However, in more than 60% of cases the genetic cause remains undiagnosed, suggesting that other genes and mechanisms must be involved in the disease development. This review aims to explore additional molecular mechanisms in recognized erythrocytosis pathways and propose new pathways associated with this rare hematological disorder. For this purpose, a comprehensive review of the literature was performed and different in silico tools were used. We identified genes involved in several mechanisms and molecular pathways, including mRNA transcriptional regulation, post-translational modifications, membrane transport, regulation of signal transduction, glucose metabolism and iron homeostasis, which have the potential to influence the main erythrocytosis-associated pathways. We provide valuable theoretical information for deeper insight into possible mechanisms of disease development. This information can be also helpful to improve the current diagnostic solutions for patients with idiopathic erythrocytosis.

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“…Erythroid progenitors in the bone marrow are stimulated by EPO to increase the production of haematopoietic stem cells and the final outcome of the process is the release of matured erythrocytes into circulation approximately seven to ten days later. 8 Renal failure due to CKD thus impedes the process as the kidney not only loses its excretory function, its endocrine function wanes and EPO production diminishes.…”

Section: Physiological Response To a Hypoxic Statementioning

confidence: 99%

Anaemia in chronic kidney disease - a review

Kok

2020

South African General Practitioner

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The management of anaemia in chronic kidney disease (CKD) patients is a complex, multifaceted process reliant on the administration of exogenous erythropoiesis stimulating agents (ESAs) and iron supplements to ensure the adequate production of viable erythrocytes. Recommended best practice guidelines should be adhered to in order to ensure favourable treatment outcomes whilst minimising the risks often associated with ESA therapy. A paucity in readily available, accurate data makes quantifying the extent to which renal anaemia affects our population and how it is managed challenging, however it is expected to follow international trends. Novel preparations for treating renal anaemia are currently in the clinical trial phase, therefore the potential benefits and risks have yet to be confirmed.

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Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA

Cited by 4 publications

References 111 publications

Epigenetic divergence during early stages of speciation in an African crater lake cichlid fish

Epigenetic divergence during early stages of speciation in an African crater lake cichlid fish

Molecular Pathways Involved in the Development of Congenital Erythrocytosis

Anaemia in chronic kidney disease - a review

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