Regulation of endothelial cells on the osteogenic ability of bone marrow mesenchymal stem cells in peri-implantitis

Xia, Yixin; Geng, Ningbo; Ren, Jing; Liao, Chunhui; Wang, Ming; Chen, Songling; Chen, Huan-Lin; Wei, Ping

doi:10.1016/j.tice.2023.102042

Cited by 2 publications

(1 citation statement)

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“…Peri-implantitis samples show a significantly higher population of M1 macrophages compared with M2-type samples. However, an excessive presence of M1 macrophages leads to increased inflammation. , Studies have demonstrated the activation of the NF-κB pathway in macrophages, which subsequently increases the number of osteoclasts and disrupts the osteogenic microenvironment. − And it is acknowledged that the bone resorption could significantly increase the risk of implant failure. Therefore, a crucial strategy for managing peri-implant diseases is to remove or prevent bacterial infection and biofilm attachment on the implant surface.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic Microenvironment Restoration around Dental Implants Induced by an Injectable MXene-Based Hydrogel

Chen,

Tao,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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Peri-implantitis is an excessive inflammatory response induced by complex interactions between the bacteria, host immune system, and tissues around the dental implant. Alveolar bone resorption caused by peri-implantitis is a significant cause of implant failure. However, to restore the osteogenic microenvironment, a multifaceted therapeutic method that simultaneously encompasses anti-inflammatory and tissue regenerative strategies is indispensable. In this study, a temperature-sensitive hydrogel (FMXO) loaded with MXene and MgO was used to develop a multifunctional injectable MXene-based hydrogel. This hydrogel could release MXene and MgO in irregular bone defect areas in situ with no toxicity, either in vitro or in vivo. Our results showed that FMXO effectively inhibited the NF-κB signaling pathway in RAW264.7 cells and simultaneously upregulated the expression of ALP, Runx2, and OCN in bone marrow mesenchymal stromal cells (BMSCs). Therefore, FMXO exerted pharmacological effects on inflammation and bone regeneration. Moreover, we found that FMXO, when exposed to near-infrared (NIR) light, exhibited high efficacy against Porphyromonas gingivalis, Fusobacterium nucleatum, and their plaque microorganisms, which were considered the initiating factors of peri-implantitis. The multifunctionality of FMXO was also confirmed in an immediate peri-implant rat model in vivo, suggesting the great potential for peri-implantitis therapy in the dental clinic.

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