Regulation of Endothelial Cell Cytoskeletal Reorganization by a Secreted Frizzled-Related Protein-1 and Frizzled 4- and Frizzled 7-Dependent Pathway

Abstract

Consistent with findings of Wnt pathway members involved in vascular cells

Cellular and Molecular Characterization of Human Cardiac Stem Cells Reveals Key Features Essential for Their Function and Safety

“…It could be proposed that the cells entered into the senescence phase, the upregulation of some metastatic and cancerrelated genes led us to hypothesis whether cell characteristics might change with increased passaging. In addition, downregulation of other genes such as secreted frizzled-related protein 1 (SFRP1), survivin (BIRC5), and BUB1, which play a role in regulation of the Wnt signaling pathway [66,67], inhibition of apoptosis [68][69][70], and regulation of spindle check point proteins [71][72][73], respectively, have supported this hypothesis. Upregulation of some developmental, metastatic, and cancer-related genes in addition to downregulation of cell cycle-related genes, which was observed in our microarray results, indicated the distinct properties of the cells in higher passages compared to those in low passages.…”

An anterior signaling center patterns and sizes the anterior neuroectoderm of the sea urchin embryo

“…sFRPs comprise the largest family of Wnt modulators in the animal kingdom (Bovolenta et al, 2008). They contain a cysteine-rich domain (CRD) that is almost identical to the CRD of the Wnt receptor Frizzled (Fzl), and several studies suggest that sFRPs could bind Wnt via this domain and inhibit the ability of Wnt to activate the Fzl receptor (Bafico et al, 1999;Bhat et al, 2007;Lin et al, 1997 (Bafico et al, 1999;Dufourcq et al, 2008;Esteve et al, 2011;Taira, 2009, 2011;Rodriguez et al, 2005). Based on these apparently conflicting results, it has been proposed that the functions of sFRPs depend on their expression levels as well as the molecular and cellular context (Bovolenta et al, 2008;Mii and Taira, 2011).…”

The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair

“…Our study also demonstrated that sFRP2 caused a robust increase in MSC therapy-induced angiogenesis. sFRP1 and 4 overexpression in endothelium have recently been shown to increase neovascularization in hindlimb ischemia by regulation of Wnt and Rac1 signaling (36). We do not know, however, whether sFRP2 works in a similar manner via direct paracrine effects on endothelial cells, indirectly via up-regulation of other angiogenic factors, or via MSC propagation.…”