Regulation of endoplasmic reticulum Ca2+ oscillations in mammalian eggs

Wakai, Toshifumi; Zhang, Nan; Vangheluwe, Peter; Fissore, Rafael A.

doi:10.1242/jcs.136549

Cited by 72 publications

(53 citation statements)

References 60 publications

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“…Disruption of mitochondrial function in oocytes rapidly depleted Ca 2+ concentrations within the cytoplasm and the ER. Mitochondrial disruption also severely attenuated and rapidly eliminated oscillations prematurely [ 47 ]. This further supports a critical role of healthy, functional mitochondria for successful fertilization.…”

Section: Fertilizationsupporting

confidence: 55%

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Boudoures

Moley

2015

Biennial Review of Infertility

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Section: Fertilizationsupporting

confidence: 55%

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Boudoures

Moley

2015

Biennial Review of Infertility

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“…However, the phosphorylation site appears to differ between the species (Lee et al 2006, Sun et al 2009). Moreover, Cdk1, a subunit of MPF, targets the IP3R to enhance its sensitivity during mouse oocyte maturation (Wakai et al 2013). Interestingly, Xenopus data showed that both Cdk1 and MAPK require simultaneous activation to mediate full sensitization of the IP3Rs (Sun et al 2009 ] ER by its EF hand domain (Lewis 2007, Carrasco & Meyer 2011.…”

Section: Inositol Trisphosphate Receptors (Ip3rs)mentioning

confidence: 99%

“…Mitochondrial ATP production is necessary for SERCA activity (Fissore et al 2002), a mechanism involved in ER replenishment (Wakai et al 2013). Mitochondria are associated with the maintenance of low basal cytoplasmic Ca 2+ levels contributing to the occurrence of the Ca 2+ oscillations (Dumollard et al 2004).…”

Section: Mitochondriamentioning

confidence: 99%

“…Mitochondria are associated with the maintenance of low basal cytoplasmic Ca 2+ levels contributing to the occurrence of the Ca 2+ oscillations (Dumollard et al 2004). In addition, mitochondrial Ca 2+ uptake has also been shown to be essential in the regulation of IP3-induced Ca 2+ release (IICR) during Ca 2+ signaling in both, Xenopus and mice oocytes (Jouaville et al 1995, Wakai et al 2013. In this regard, the protein MICU1 (mitochondrial calcium uptake 1) plays a principal role for Ca 2+ uptake into the mitochondrial matrix (Perocchi et al 2010).…”

Section: Mitochondriamentioning

confidence: 99%

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Single Ca2+ transients vs oscillatory Ca2+ signaling for assisted oocyte activation: limitations and benefits

et al. 2018

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“…Mitochondria also regulate calcium oscillations during fertilization, which are crucial for embryonic development [33]. The pattern of calcium oscillations changes when mitochondria function is inhibited [34]. Moreover, mitochondrial function and DNA content determines fertilization outcome of porcine oocytes [35,36].…”

Section: Mitochondria and Reproductionmentioning

confidence: 99%

Oocyte mitochondrial function and reproduction

Babayev

Seli²

2015

Current Opinion in Obstetrics &Amp; Gynecology

244

179

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Purpose of review Mitochondria are cellular organelles that are required for energy production. Emerging evidence demonstrates their role in oocyte development and reproduction. In this review, we examine recent animal and clinical studies on the role of mitochondria in fertility. We also analyse the impact of assisted reproductive techniques (ARTs) on mitochondrial function and discuss the future clinical implications of mitochondrial nutrients and mitochondrial replacement. Recent findings Mitochondria affect all aspects of mammalian reproduction. They are essential for optimal oocyte maturation, fertilization and embryonic development. Mitochondrial dysfunction causes a decrease in oocyte quality and interferes with embryonic development. ART procedures affect mitochondrial function, while mitochondrial nutrients may increase mitochondrial performance in oocytes. New mitochondrial replacement procedures using mitochondria obtained from polar bodies or from the patient’s own oogonial stem cells are promising and may address concerns related to the induction of high-levels of heteroplasmy, which could potentially result in negative long-term health effects. Summary Optimal energy production is required for oocyte and embryo development, and mitochondrial abnormalities have devastating reproductive consequences. Improvement of oocyte mitochondrial function via intake of compounds that boost mitochondrial activity may have clinical benefits, and mitochondrial replacement could potentially be used for the prevention of mitochondrial diseases.

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Regulation of endoplasmic reticulum Ca2+ oscillations in mammalian eggs

Cited by 72 publications

References 60 publications

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Single Ca2+ transients vs oscillatory Ca2+ signaling for assisted oocyte activation: limitations and benefits

Oocyte mitochondrial function and reproduction

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