The Dopamine Receptors 1997
DOI: 10.1007/978-1-4757-2635-0_13
|View full text |Cite
|
Sign up to set email alerts
|

Regulation of Dopamine Receptor Function and Expression

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
13
0

Year Published

1997
1997
2014
2014

Publication Types

Select...
6
3

Relationship

3
6

Authors

Journals

citations
Cited by 24 publications
(14 citation statements)
references
References 154 publications
1
13
0
Order By: Relevance
“…The results of these studies revealed that persistent treatment with quinpirole (10 M), sulpiride (1 M), or quinpirole ϩ sulpiride significantly increased D 2L receptor density (118 Ϯ 6, 149 Ϯ 17, or 129 Ϯ 9%; n ϭ 5) compared with vehicle treatment (100%). These ligand-induced increases in D 2L receptor expression are consistent with our previous report (Vidi et al, 2008a) and work from others (Sibley and Neve, 1997). No significant changes in CB 1 receptor density were observed upon persistent treatment with either of the D 2 receptor ligands alone or the combination (data not shown).…”
Section: Resultssupporting
confidence: 92%
“…The results of these studies revealed that persistent treatment with quinpirole (10 M), sulpiride (1 M), or quinpirole ϩ sulpiride significantly increased D 2L receptor density (118 Ϯ 6, 149 Ϯ 17, or 129 Ϯ 9%; n ϭ 5) compared with vehicle treatment (100%). These ligand-induced increases in D 2L receptor expression are consistent with our previous report (Vidi et al, 2008a) and work from others (Sibley and Neve, 1997). No significant changes in CB 1 receptor density were observed upon persistent treatment with either of the D 2 receptor ligands alone or the combination (data not shown).…”
Section: Resultssupporting
confidence: 92%
“…3. Dopamine receptors are subjected to a variety of regulatory mechanisms which can either positively or negatively modulate their expression and functional activity (13). The mechanisms underlying the different forms of dopamine receptor regulation have not yet been completely elucidated.…”
Section: Functional Characteristics Of Dopamine Receptorsmentioning
confidence: 99%
“…Several studies on dopamine receptors have demonstrated that the D 1 receptor displays a comparable mechanism of desensitization, although some difference exists from the classical scheme. In contrast, the regulation of D 2 receptors seems extremely complex with receptor activation variably resulting in functional desensitization, sensitization, up-or down-regulation (13). The regulation of D 2 receptors seems to be influenced by the type and concentration of the agonist or antagonist, the receptor isoform and the cell system.…”
Section: Functional Characteristics Of Dopamine Receptorsmentioning
confidence: 99%
“…Desensitization and internalization of the dopamine D2 receptor have been described in a variety of cell lines and tissue preparations (Barton et al, 1991;Zhang et al, 1994;Boundy et al, 1995;Ng et al, 1997;Sibley and Neve, 1997;Vickery and von Zastrow, 1999;Kim et al, 2001Kim et al, , 2004. The interaction of arrestins and the dopamine D2 receptor and the contribution of this interaction to receptor internalization have also been investigated but chiefly in studies using heterologous expression of arrestins, GRKs, and the D2 receptor in non-neuronal cells.…”
mentioning
confidence: 99%