Regulation of Dendritic Cell Function by Surfactant Protein D

Kierstein, S.; Hortobagyi, L.; Krytska, Kateryna; Haczku, Angela Franciska

doi:10.1016/j.jaci.2006.12.531

Cited by 1 publication

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“…Nevertheless, in our model of A. fumigatus ‐induced allergic airway inflammation, the Ccl17‐Ccr4 and Ccl19/21‐Ccr7 ligand–receptor pairs were significantly up‐regulated at the mRNA level in a time‐dependent manner indicating the importance of these genes in immune cell migration in response to allergen inhalation. The expression of the Ccr4 ligand Ccl17 was selectively induced while the expression of Ccr7 was selectively abolished in vivo in SP‐D‐/‐ mice [165, 166]. The significance of this effect of SP‐D on the Ccr7 expression is that this receptor was shown to be specific not only for lymph node homing but also for immune tolerance [167].…”

Section: Effects Of Surfactant Protein D On Dendritic Cellsmentioning

confidence: 99%

“… Hypothetic role of SP‐D in dendritic cell migration. In Aspergillus fumigatus ‐induced allergic airway inflammation, the Ccl17‐Ccr4 and Ccl19/21‐Ccr7 ligand–receptor pairs were significantly up‐regulated at the mRNA level in a time‐dependent manner in mice [4, 165, 166]. (a) SP‐D prevents the epithelial migration of myeloid dendritic cells by inhibiting autocrine Ccl17 release.…”

Section: Effects Of Surfactant Protein D On Dendritic Cellsmentioning

confidence: 99%

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SP‐D and regulation of the pulmonary innate immune system in allergic airway changes

Forbes

Haczku

2010

Clin Experimental Allergy

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The airway mucosal surfaces are constantly exposed to inhaled particles that can be potentially toxic, infectious or allergenic and should elicit inflammatory changes. The proximal and distal air spaces, however, are normally infection and inflammation free due to a specialized interplay between cellular and molecular components of the pulmonary innate immune system. Surfactant protein D (SP-D) is an epithelial-cell-derived immune modulator that belongs to the small family of structurally related Ca(2+)-dependent C-type collagen-like lectins. While collectins can be detected in mucosal surfaces of various organs, SP-A and SP-D (the 'lung collectins') are constitutively expressed in the lung at high concentrations. Both proteins are considered important players of the pulmonary immune responses. Under normal conditions however, SP-A-/- mice display no pathological features in the lung. SP-D-/- mice, on the other hand, show chronic inflammatory alterations indicating a special importance of this molecule in regulating immune homeostasis and the function of the innate immune cells. Recent studies in our laboratory and others implied significant associations between changes in SP-D levels and the presence of airway inflammation both in animal models and patients raising a potential usefulness of this molecule as a disease biomarker. Research on wild-type and mutant recombinant molecules in vivo and in vitro showed that SP-D binds carbohydrates, lipids and nucleic acids with a broad spectrum specificity and initiates phagocytosis of inhaled pathogens as well as apoptotic cells. Investigations on gene-deficient and conditional over expressor mice in addition, provided evidence that SP-D directly modulates macrophage and dendritic cell function as well as T cell-dependent inflammatory events. Thus, SP-D has a unique, dual functional capacity to induce pathogen elimination on the one hand and control of pro-inflammatory mechanisms on the other, suggesting a potential suitability for therapeutic prevention and treatment of chronic airway inflammation without compromising the host defence function of the airways. This paper will review recent findings on the mechanisms of immune-protective function of SP-D in the lung.

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Section: Effects Of Surfactant Protein D On Dendritic Cellsmentioning

confidence: 99%

Section: Effects Of Surfactant Protein D On Dendritic Cellsmentioning

confidence: 99%