Regulation of dendrite morphogenesis by extrinsic cues

Valnegri, Pamela; Puram, Sidharth V.; Bonni, Azad

doi:10.1016/j.tins.2015.05.003

Cited by 68 publications

(50 citation statements)

References 99 publications

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“…These results were surprising in the context of reported developmental functions for Wnt5a in cultured hippocampal neurons, and in embryonic processes in other brain regions (15,18,19). In hippocampal neurons, several signaling pathways have been shown to influence dendrite morphogenesis, maturation, and stability in vitro and in vivo (1,6,69). Thus, in the absence of Wnt5a, other signaling mechanisms, including other Wnt molecules (26,27), could provide trophic support to hippocampal CA1 dendrite arbors and spines at least for the first several months of life in mice.…”

Section: Discussionmentioning

confidence: 97%

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Chen

Orefice

Chiu

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Stability of neuronal connectivity is critical for brain functions, and morphological perturbations are associated with neurodegenerative disorders. However, how neuronal morphology is maintained in the adult brain remains poorly understood. Here, we identify Wnt5a, a member of the Wnt family of secreted morphogens, as an essential factor in maintaining dendritic architecture in the adult hippocampus and for related cognitive functions in mice. Wnt5a expression in hippocampal neurons begins postnatally, and its deletion attenuated CaMKII and Rac1 activity, reduced GluN1 glutamate receptor expression, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice. With increased age, Wnt5a loss caused progressive attrition of dendrite arbors and spines in Cornu Ammonis (CA)1 pyramidal neurons and exacerbated behavioral defects. Wnt5a functions cell-autonomously to maintain CA1 dendrites, and exogenous Wnt5a expression corrected structural anomalies even at late-adult stages. These findings reveal a maintenance factor in the adult brain, and highlight a trophic pathway that can be targeted to ameliorate dendrite loss in pathological conditions. autocrine Wnt signaling | dendrite arbors | adult hippocampus

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Section: Discussionmentioning

confidence: 97%

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Chen

Orefice

Chiu

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…The adhesion molecules, in turn, interact with environmental cues, leading to appropriate patterns of dendritic growth and arborization (Parrish et al, 2007; Santiago and Bashaw, 2014). It is likely that this logic is evolutionally conserved (Cubelos et al, 2010; Peng et al, 2009; Puram and Bonni, 2013; Valnegri et al, 2015; Whitney et al, 2014), but in few if any cases have genetic programs been identified that control individual features within complex dendrites.…”

Section: Introductionmentioning

confidence: 99%

Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell

Peng

Tran

Krishnaswamy

et al. 2017

Neuron

110

140

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SUMMARY The size and shape of dendritic arbors are prime determinants of neuronal connectivity and function. We asked how ON-OFF direction-selective ganglion cells (ooDSGCs) in mouse retina acquire their bistratified dendrites, in which responses to light-onset and light-offset are segregated to distinct strata. We found that the transcriptional regulator Satb1 is selectively expressed by ooDSGCs. In Satb1 mutant mice, ooDSGC dendrites lack ON arbors and the cells selectively lose ON responses. Satb1 regulates expression of a homophilic adhesion molecule, Contactin 5 (Cntn5). Both Cntn5 and its co-receptor Caspr4 are expressed not only by ooDSGCs but also by interneurons that form a scaffold on which ooDSGC ON dendrites fasciculate. Removing Cntn5 from either ooDSGCs or the interneurons partially phenocopies Satb1 mutants, demonstrating that Satb1-dependent Cntn5 expression in ooDSGCs leads to branch-specific homophilic interactions with interneurons. Thus, Satb1 directs formation of a morphologically and functionally specialized compartment within a complex dendritic arbor.

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“…During development, overall dendritic gestalt is determined by innate genetic factors (Montague and Friedlander, 1989; Grueber et al, 2003; Gao and Bogert, 2003; Puram and Bonni, 2013), and external molecular cues (McAllister, 2002; Polleux and Ghosh, 2008; Valnegri et al, 2015) guide growth into the correct neuropil regions. In addition, both overall dendritic growth rates and the fine tuning of high order branching often require activity-dependent control (Cline, 2001).…”

Section: Introductionmentioning

confidence: 99%

Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material

Ryglewski

Vonhoff

Scheckel

et al. 2017

Neuron

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SUMMARY Brain development requires correct targeting of multiple thousand synaptic terminals onto staggeringly complex dendritic arbors. The mechanisms by which input synapse numbers are matched to dendrite size, and by which synaptic inputs from different transmitter systems are correctly partitioned onto a postsynaptic arbor, are incompletely understood. By combining quantitative neuroanatomy with targeted genetic manipulation of synaptic input to an identified Drosophila neuron, we show that synaptic inputs of two different transmitter classes locally direct dendrite growth in a competitive manner. During development, the relative amounts of GABAergic and cholinergic synaptic drive shift dendrites between different input domains of one postsynaptic neuron without affecting total arbor size. Therefore, synaptic input locally directs dendrite growth, but intra-neuronal dendrite redistributions limit morphological variability, a phenomenon also described for cortical neurons. Mechanistically, this requires local dendritic Ca2+ influx through Dα7nAChRs or through LVA channels following GABAAR-mediated depolarizations.

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Regulation of dendrite morphogenesis by extrinsic cues

Cited by 68 publications

References 99 publications

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell

Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material

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