Avik Roy, Malabendu Jana, Grant T. Corbett, Shilpa Ramaswamy, Jeffrey H. Kordower, Frank J. Gonzalez, Kalipada Pahan
Peroxisome proliferator-activated receptor (PPAR) α is a transcription factor that regulates genes involved in fatty acid catabolism. Here we provide evidence that PPARα is constitutively expressed in nuclei of hippocampal neurons and surprisingly controls calcium influx and the expression of various plasticity-related genes via direct transcriptional regulation of CREB. Accordingly, Ppara-null, but not Pparb-null, mice are deficient in CREB and memory-associated genes, and have decreased spatial learning and…
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