Cell Reports volume 4, issue 4, P724-737 2013 DOI: 10.1016/j.celrep.2013.07.028 View full text
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Avik Roy, Malabendu Jana, Grant T. Corbett, Shilpa Ramaswamy, Jeffrey H. Kordower, Frank J. Gonzalez, Kalipada Pahan

Abstract: Peroxisome proliferator-activated receptor (PPAR) α is a transcription factor that regulates genes involved in fatty acid catabolism. Here we provide evidence that PPARα is constitutively expressed in nuclei of hippocampal neurons and surprisingly controls calcium influx and the expression of various plasticity-related genes via direct transcriptional regulation of CREB. Accordingly, Ppara-null, but not Pparb-null, mice are deficient in CREB and memory-associated genes, and have decreased spatial learning and…

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