Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells

Tamura, Masato; Sato, Mari; Nashimoto, Masayuki

doi:10.1016/j.biocel.2011.01.021

Cited by 47 publications

(38 citation statements)

References 42 publications

(47 reference statements)

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“…There have been other factors reported to regulate Cxcl12 and include the canonical (Tamura et al, 2011) and non-canonical Wnt signaling (Tamura et al, 2011; Witze et al, 2008), Hypoxia-inducible factor-1 and 2 (Ceradini et al, 2004; Martin et al, 2010), and VegfA (Hong et al, 2006). Hence, some of these factors may also be responsible for regulating Cxcl12 expression independent of Pitx2.…”

Section: Discussionmentioning

confidence: 99%

The Left-Right Pitx2 Pathway Drives Organ-Specific Arterial and Lymphatic Development in the Intestine

et al. 2014

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SUMMARY The dorsal mesentery (DM) is the major conduit for blood and lymphatic vessels in the gut. The mechanisms underlying their morphogenesis are challenging to study and remain unknown. Here we show that arteriogenesis in the DM begins during gut rotation and proceeds strictly on the left side, dependent on the Pitx2 target gene Cxcl12. Although competent Cxcr4-positive angioblasts are present on the right, they fail to form vessels and progressively emigrate. Surprisingly, gut lymphatics also initiate in the left DM and arise only after – and dependent on – arteriogenesis, implicating arteries as drivers of gut lymphangiogenesis. Our data begin to unravel the origin of two distinct vascular systems and demonstrate how early L-R molecular asymmetries are translated into organ-specific vascular patterns. We propose a dual origin of gut lymphangiogenesis, where prior arterial growth is required to initiate local lymphatics that only subsequently connect to the vascular system.

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Section: Discussionmentioning

confidence: 99%

The Left-Right Pitx2 Pathway Drives Organ-Specific Arterial and Lymphatic Development in the Intestine

et al. 2014

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“…MLO-Y4 cells were cultured in α-modified minimum essential medium (Sigma-Aldrich) containing 10% fetal bovine serum (SAFC Bioscience, Inc., Lenexa, KS, USA) with 100 µg/ml kanamycin (Meiji, Ltd., Tokyo, Japan) and maintained in plates or flasks coated with 0.15 mg/ml rat tail collagen type I (BD Biosciences, Bedford, MA, USA) at 37˚C in a humidified atmosphere of 5% CO 2 in air. In addition, the mouse stromal ST2 cell line was obtained from the RIKEN Cell Bank (Tsukuba, Japan), and cells were cultured as described previously (19).…”

Section: Methodsmentioning

confidence: 99%

Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells

et al. 2016

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Abstract. Signaling molecules produced by osteocytes have been proposed to serve as soluble factors that contribute to bone remodeling, as well as to homeostasis of other organs. However, to the best of our knowledge, there are currently no studies investigating the role of osteocyte-secreted exosomes. In the present study, ablation of osteocytes in mice [osteocyte-less (OL)] was used to examine the microRNA (miRNA) levels of plasma-circulating exosomes. In order to investigate the function of osteocyte-secreted exosomes, exosomes derived from MLO-Y4 cells were extracted and their miRNA expression levels were examined using miRNA array analysis and deep sequencing. Comparison of miRNA expression levels between plasma exosomes from OL mouse plasma and MLO-Y4-derived exosomes revealed that decreases in the number of miRNAs from exosomes circulating in the OL mouse plasma may be caused by a decrease in secretion of exosomes from osteocytes. These results suggest that osteocytes secrete exosomes containing characterized miRNAs and then circulate in the blood, and may thus transfer their components, including miRNAs, to recipient cells where they function as signaling molecules in other organs and/or tissues to regulate biological responses.

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“…Given that our work has demonstrated an association for 5T4 in the ability of cancer cells to activate both routes, it is feasible that 5T4 is involved in the synergy of these two important pathways. Indeed, there is data that suggest a synergistic role for Wnt and CXCR4-mediated signalling in cancer [56][57][58].…”

Section: T4 Modulation Of Wnt Signallingmentioning

confidence: 97%

Understanding and exploiting 5T4 oncofoetal glycoprotein expression

Stern

Brazzatti

Sawan

et al. 2014

Seminars in Cancer Biology

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Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells

Cited by 47 publications

References 42 publications

The Left-Right Pitx2 Pathway Drives Organ-Specific Arterial and Lymphatic Development in the Intestine

The Left-Right Pitx2 Pathway Drives Organ-Specific Arterial and Lymphatic Development in the Intestine

Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells

Understanding and exploiting 5T4 oncofoetal glycoprotein expression

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