Regulation of Cued Fear Expression via Corticotropin-Releasing-Factor Neurons in the Ventral Anteromedial Thalamic Nucleus

Lv, Yin; Chen, Peng; Shan, Qing-Hong; Qin, Xin-Ya; Qi, Xiu-Hong; Zhou, Jiang‐Ning

doi:10.1007/s12264-020-00592-6

Cited by 8 publications

(1 citation statement)

References 36 publications

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“…The AM CRH neurons have been shown to play a role in regulating conditioned fear memory (Lv et al., 2021). Anatomically, there were wide excitatory cortico‐thalamo‐cortical connections in the MD, particularly with the PFC.…”

Section: Resultsmentioning

confidence: 99%

Whole‐brain mapping of monosynaptic afferent inputs to the CRH neurons in the medial prefrontal cortex of mice

Li,

Zhu

et al. 2023

Journal of Anatomy

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Corticotropin‐releasing hormone (CRH) neurons are densely distributed in the medial prefrontal cortex (mPFC), which plays a crucial role in integrating and processing emotional and cognitive inputs from other brain regions. Therefore, it is important to know the neural afferent patterns of mPFCCRH neurons, which are still unclear. Here, we utilized a rabies virus‐based monosynaptic retrograde tracing system to map the presynaptic afferents of the mPFCCRH neurons throughout the entire brain. The results show that the mPFCCRH neurons receive inputs from three main groups of brain regions: (1) the cortex, primarily the orbital cortex, somatomotor areas, and anterior cingulate cortex; (2) the thalamus, primarily the anteromedial nucleus, mediodorsal thalamic nucleus, and central medial thalamic nucleus; and (3) other brain regions, primarily the basolateral amygdala, hippocampus, and dorsal raphe nucleus. Taken together, our results are valuable for further investigations into the roles of the mPFCCRH neurons in normal and neurological disease states. These investigations can shed light on various aspects such as cognitive processing, emotional modulation, motivation, sociability, and pain.

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Section: Resultsmentioning

confidence: 99%