Regulation of cornifin α expression in the vaginal and uterine epithelium by estrogen and retinoic acid

Jetten, Anton M.; Luca, Luigi M. De; Nelson, Kay M.; Schroeder, W. T.; Burlingame, Sue; Fujimoto, Wataru

doi:10.1016/0303-7207(96)03871-3

Cited by 24 publications

(15 citation statements)

References 34 publications

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“…Vitamin A deficiency, or exposure to either natural or synthetic estrogens (e.g., diethylstilbestrol [DES]), greatly enhanced the squamous differentiation and keratinization of vaginal epithelium in ovariectomized animals. The latter effect was again associated with a dramatic induction of the cornifin ␣ gene (Jetten et al, 1996).…”

Section: Discussionmentioning

confidence: 91%

Pathology of Aural Abscesses in Free-Living Eastern Box Turtles (Terrapene Carolina Carolina)

Brown

Richards

Robertson

et al. 2004

Journal of Wildlife Diseases

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Aural abscess or abscess of the middle ear is common in free-living Eastern box turtles (Terrapene carolina carolina) of Virginia (USA) and elsewhere. Although its etiology remains unknown, hypovitaminosis A has been suggested on the basis of similar lesions occurring in captive chelonians fed diets that are deficient in vitamin A. This hypothesis was supported by significantly greater body burdens of organochlorine compounds (reported disruptors of vitamin A metabolism) and a nonsignificant trend toward lower serum and hepatic vitamin A levels in free-living box turtles with this lesion. The tympanic epithelium was evaluated in 27 box turtles (10 with aural abscesses and 17 without). Lesions of the tympanic epithelium of box turtles with aural abscesses included hyperplasia, squamous metaplasia, hyperemia, cellular sloughing, granulomatous inflammation, and bacterial infection. These changes were more severe in turtles with aural abscesses than in those without and were more severe in tympanic cavities that had an abscess compared to those without when the lesion was unilateral. Organs from 21 box turtles (10 with aural abscesses and 11 without) from the study population were examined for microscopic lesions, and minimal histopathologic changes were found, none of which were similar to those found in the tympanic epithelium. Histopathologic changes in box turtles with aural abscesses were consistent with a syndrome that may involve hypovitaminosis A.

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Section: Discussionmentioning

confidence: 91%

Pathology of Aural Abscesses in Free-Living Eastern Box Turtles (Terrapene Carolina Carolina)

Brown

Richards

Robertson

et al. 2004

Journal of Wildlife Diseases

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“…Therefore, the question of the novel role of sprr2 proteins in the reproductive process has arisen. It is thought that these uterine CE precursors might reflect a predisposition of this epithelium to undergo squamoid differentiation under certain conditions [15]. However, there is little further report on their regulation and function in the reproductive tissues so far.…”

Section: Introductionmentioning

confidence: 99%

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Tan

Sun

et al. 2006

Reprod. Nutr. Dev.

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-Small proline-rich proteins (SPRR) are known to construct the cornified cell envelope (CE) in the stratified squamous epithelial cell. Their functions in the simple epithelium such as the uterine epithelium are not clear hitherto. In the present study, the mRNA expression patterns of sprr2 family members in the mouse uterus and vagina during the estrous cycle and pregnancy as well as their regulation by steroids were investigated. Using semi-quantitative RT-PCR, it was revealed that the transcripts of sprr2b, 2e and 2g genes were up-regulated in the proestrous and estrous uteri, and sprr2d was up-regulated only in the estrous uterus. In the vagina, transcription of sprr2a, 2b, 2d, 2e and 2k genes were up-regulated at the metestrous stage. Northern blot analysis demonstrated that the overall expression of sprr2 was highly up-regulated in the estrous uterus and the metestrous vagina. During pregnancy, the sprr2 mRNA in the uterus was sharply repressed from day 3 postcoitus on, and began to be induced around labor time. In situ hybridization showed that the sprr2 transcripts were localized in uterine luminal and glandular epithelial cells as well as vaginal stratified epithelial cells. In ovariectomized mice, the expression of sprr2a, 2d, 2e and 2f genes in the uterus were induced by estrogen, and the effect of estrogen on sprr2d and 2e expression could be partly abolished by progesterone. The data indicate that the sprr2 genes have unique regulation patterns in different reproductive tissues under different physiological conditions, and the encoded proteins might play diverse functions in the female reproductive system. small proline-rich protein / uterus / estrous cycle / pregnancy / stress

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“…Rdh10 and Aldh1a2 expression are significantly higher in the uteri of postnatal mice than those in their vaginas from postnatal day 2 (P2) to P90 (Nakajima et al 2016). Moreover, mice fed from birth with vitamin A-deficient diets for 10 or 14 weeks exhibit squamous metaplasia in their uterine epithelia (Darwiche et al 1993, Jetten et al 1996. These data suggest a critical role of RA signaling in maintaining uterine epithelium.…”

Section: Retinoid Action In Endometrial Differentiation and Developmentmentioning

confidence: 88%

Physiological and pathological implications of retinoid action in the endometrium

Jiang

Chen

Taylor

et al. 2018

Journal of Endocrinology

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Retinol (vitamin A) and its derivatives, collectively known as retinoids, are required for maintaining vision, immunity, barrier function, reproduction, embryogenesis and cell proliferation and differentiation. Despite the fact that most events in the endometrium are predominantly regulated by steroid hormones (estrogens and progesterone), accumulating evidence shows that retinoid signaling is also involved in the development and maintenance of the endometrium, stromal decidualization and blastocyst implantation. Moreover, aberrant retinoid metabolism seems to be a critical factor in the development of endometriosis, a common gynecological disease, which affects up to 10% of reproductive age women and is characterized by the ectopic localization of endometrial-like tissue in the pelvic cavity. This review summarizes recent advances in research on the mechanisms and molecular actions of retinoids in normal endometrial development and physiological function. The potential roles of abnormal retinoid signaling in endometriosis are also discussed. The objectives are to identify limitations in current knowledge regarding the molecular actions of retinoids in endometrial biology and to stimulate new investigations toward the development potential therapeutics to ameliorate or prevent endometriosis symptoms.

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Regulation of cornifin α expression in the vaginal and uterine epithelium by estrogen and retinoic acid

Cited by 24 publications

References 34 publications

Pathology of Aural Abscesses in Free-Living Eastern Box Turtles (Terrapene Carolina Carolina)

Pathology of Aural Abscesses in Free-Living Eastern Box Turtles (Terrapene Carolina Carolina)

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Physiological and pathological implications of retinoid action in the endometrium

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