Regulation of cocaine-related behaviours by estrogen and progesterone

Peart, Davin R; Andrade, Allyson K.; Logan, Carly N.; Knackstedt, Lori A.; Murray, Jennifer E.

doi:10.1016/j.neubiorev.2022.104584

Cited by 20 publications

(11 citation statements)

References 389 publications

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“…Global [ 65 ] and brain region specific [ 66 ] loss of δ subunit-containing GABA A receptors drove reductions in ethanol intake, though this may be specific to discrete anatomical substrates [ 66 ]. In addition to direct effects on reward seeking of progesterone as reported here and elsewhere [ 29 , 32 , 60 , 67 ], progesterone administration can also modulate anxiety-like behavior [ 68 ], which may be mediated through its effects on the GABAA receptor [ 64 , 69 ]. This suggests that there may be dual mechanisms by which progesterone may act to blunt stress-induced reinstatement, potentially through actions on the GABAergic system – general suppression of response to acute stressors or suppression of reward-seeking behavior.…”

Section: Discussionmentioning

confidence: 74%

“…Indeed, findings on ethanol intake across the menstrual cycle in women suggest interactions between estradiol and progesterone levels contribute to drinking [ 31 ]. It will be important in future studies to determine whether approaches to reducing stress-induced reinstatement are similarly efficacious under all hormonal conditions, especially as estradiol may confer risk for drug seeing behavior c.f., [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice

Giacometti

Buck

Barker

2022

Addiction Neuroscience

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice

Giacometti

Buck

Barker

2022

Addiction Neuroscience

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“…Substance use disorders such as cocaine misuse are more prevalent in female animals (reviewed in McHugh et al 2018;Radke et al 2021) and humans (reviewed in Becker et al 2012;Becker 2016). This is believed to be facilitated by female levels of E2 (Hu et al 2004;Quinones-Jenab and Jenab 2010;Peart et al 2022). For example, E2-treated OVX female rats display cocaine self-administration sooner and at lower doses compared to untreated OVX females and males (Hu et al 2004).…”

Section: Orexin-mediated Reward-related Behavior Across the Estrous C...mentioning

confidence: 99%

Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle

2022

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Rationale The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter orexin or hypocretin peptide production and receptor activity. Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA, post-translational modification of orexin peptide, and abundance of orexin receptors change in a brain region-specific manner. The most dramatic changes occur in the hypothalamus, which is considered the starting point of the hypothalamic-pituitary–gonadal axis as well as the hub of orexin-producing neurons. Thus, hypothalamus-regulated behaviors, including arousal, feeding, reward processing, and the stress response depend on coordinated efforts between E2, progesterone, and the orexin system. Given the rise of orexin therapeutics for various neuropsychiatric conditions including insomnia and affective disorders, it is important to delineate the behavioral outcomes of this drug class in both sexes, as well as within different time points of the female reproductive cycle. Objectives Summarize how the menstrual or estrous cycle affects orexin system functionality in animal models in order to predict how orexin pharmacotherapies exert varying degrees of behavioral effects across the dynamic hormonal milieu.

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“…Recently, the influence of ovarian hormones on drug-related behaviors has been of great interest (for review, see Knouse and Briand, 2021 ; Nicolas et al, 2022 ; Peart et al, 2022 ). To our knowledge, only two preclinical studies have explored the role of ovarian hormones in nicotine self-administration, only one of which was conducted outside our laboratory.…”

Section: Introductionmentioning

confidence: 99%

Ovarian Hormones Regulate Nicotine Consumption and Accumbens Glutamatergic Plasticity in Female Rats

Maher

Kipp²,

Leyrer‐Jackson³

et al. 2022

eNeuro

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Women report greater cigarette cravings during the menstrual cycle phase with higher circulating levels of 17β-estradiol (E2), which is metabolized to estrone (E1). Both E2 and E1 bind to estrogen receptors (ERs), which have been highly studied in the breast, uterus, and ovary. Recent studies have found that ERs are also located on GABAergic medium spiny neurons (MSNs) within the nucleus accumbens core (NAcore). Glutamatergic plasticity in NAcore MSNs is altered following nicotine use; however, it is unknown whether estrogens impact this neurobiological consequence. To test the effect of estrogen on nicotine use, we ovariectomized (OVX) female rats that then underwent nicotine self-administration acquisition and compared them to ovary-intact (sham) rats. The OVX animals then received either sesame oil (vehicle), E2, or E1+E2 supplementation for 4 or 20 d before nicotine sessions. While both ovary-intact and OVX females readily discriminated levers, OVX females consumed less nicotine than sham females. Further, neither E2 nor E1+E2 increased nicotine consumption back to sham levels following OVX, regardless of the duration of the treatment. OVX also rendered NAcore MSNs in a potentiated state following nicotine self-administration, which was reversed by 4 d of systemic E2 treatment. Finally, we found that E2 and E1+E2 increased ERα mRNA in the NAcore, but nicotine suppressed this regardless of hormone treatment. Together, these results show that estrogens regulate nicotine neurobiology, but additional factors may be required to restore nicotine consumption to ovary-intact levels.

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Regulation of cocaine-related behaviours by estrogen and progesterone

Cited by 20 publications

References 389 publications

Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice

Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice

Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle

Ovarian Hormones Regulate Nicotine Consumption and Accumbens Glutamatergic Plasticity in Female Rats

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