Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix

Korpayev, Serdar; Toprak, Özge; Kaygusuz, Gülşah; Şen, Murat; Orhan, Kaan; Karakeçili, Ayşe

doi:10.1016/j.colsurfb.2020.111111

Cited by 8 publications

(8 citation statements)

References 40 publications

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“…109,110 ATDC 5 chondrocytes can survive well in this multilayer hydrogel without growth factors. 109,110 Chitosan can be easily modified. 9 Modification of chitosan by natural chemical cross-linking A B Perrier-Groult et al 107 ).…”

Section: Agarose/collagen Composite Hydrogelsmentioning

confidence: 95%

“…The development of multilayer hydrogels is an effective strategy to model the multilayered structure of osteochondral tissue. Chitosan, collagen, and nano‐hydroxyapatite were combined in a bionic way to form a multilayer hydrogel, and these nanocomposite hydrogels were promising strategies for regenerating articular cartilage tissue 109,110 . ATDC 5 chondrocytes can survive well in this multilayer hydrogel without growth factors 109,110 .…”

Section: Organic Polymers/collagen Composite Hydrogelmentioning

confidence: 99%

“…Chitosan, collagen, and nano‐hydroxyapatite were combined in a bionic way to form a multilayer hydrogel, and these nanocomposite hydrogels were promising strategies for regenerating articular cartilage tissue 109,110 . ATDC 5 chondrocytes can survive well in this multilayer hydrogel without growth factors 109,110 . Chitosan can be easily modified 9 .…”

Section: Organic Polymers/collagen Composite Hydrogelmentioning

confidence: 99%

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Collagen‐Based Hydrogels for Cartilage Regeneration

Sun,

Xu,

Han

et al. 2023

Orthopaedic Surgery

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Cartilage regeneration remains difficult due to a lack of blood vessels. Degradation of the extracellular matrix (ECM) causes cartilage defects, and the ECM provides the natural environment and nutrition for cartilage regeneration. Until now, collagen hydrogels are considered to be excellent material for cartilage regeneration due to the similar structure to ECM and good biocompatibility. However, collagen hydrogels also have several drawbacks, such as low mechanical strength, limited ability to induce stem cell differentiation, and rapid degradation. Thus, there is a demanding need to optimize collagen hydrogels for cartilage regeneration. In this review, we will first briefly introduce the structure of articular cartilage and cartilage defect classification and collagen, then provide an overview of the progress made in research on collagen hydrogels with chondrocytes or stem cells, comprehensively expound the research progress and clinical applications of collagen‐based hydrogels that integrate inorganic or organic materials, and finally present challenges for further clinical translation.

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Section: Agarose/collagen Composite Hydrogelsmentioning

confidence: 95%

Section: Organic Polymers/collagen Composite Hydrogelmentioning

confidence: 99%

Section: Organic Polymers/collagen Composite Hydrogelmentioning

confidence: 99%

See 1 more Smart Citation

Collagen‐Based Hydrogels for Cartilage Regeneration

Sun,

Xu,

Han

et al. 2023

Orthopaedic Surgery

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“…[ 37,38 ] With the number of hypertrophic chondrocytes increasing, cartilage loses its normal function and then develops osteoarthritis, as manifested by increased thickness, reduced elasticity, matrix calcification, and degradation. [ 39 ] The calcified cartilage also inhibits the growth of blood vessels into cartilage, [ 40 ] and its functions are separating the cartilage and subchondral bone microenvironments to prevent the cross‐migration of cells and promote cell growth in the respective regions. [ 41 ] The chondrocytes and osteoblasts have been separated by a cell‐free region in the gradient triphasic scaffold with pores of 2.8−9.05 μm as the interfacial layer to mimic calcified cartilage structures (Figure 1C).…”

Section: Repair Of Osteochondral Defects With Gradient Scaffoldsmentioning

confidence: 99%

Bioinspired gradient scaffolds for osteochondral tissue engineering

Peng,

Zhuang,

Liu

et al. 2023

Exploration

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Repairing articular osteochondral defects present considerable challenges in self‐repair due to the complex tissue structure and low proliferation of chondrocytes. Conventional clinical therapies have not shown significant efficacy, including microfracture, autologous/allograft osteochondral transplantation, and cell‐based techniques. Therefore, tissue engineering has been widely explored in repairing osteochondral defects by leveraging the natural regenerative potential of biomaterials to control cell functions. However, osteochondral tissue is a gradient structure with a smooth transition from the cartilage to subchondral bone, involving changes in chondrocyte morphologies and phenotypes, extracellular matrix components, collagen type and orientation, and cytokines. Bioinspired scaffolds have been developed by simulating gradient characteristics in heterogeneous tissues, such as the pores, components, and osteochondrogenesis‐inducing factors, to satisfy the anisotropic features of osteochondral matrices. Bioinspired gradient scaffolds repair osteochondral defects by altering the microenvironments of cell growth to induce osteochondrogenesis and promote the formation of osteochondral interfaces compared with homogeneous scaffolds. This review outlines the meaningful strategies for repairing osteochondral defects by tissue engineering based on gradient scaffolds and predicts the pros and cons of prospective translation into clinical practice.

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“…The gradients of cell phenotype and its associated ECM composition of OC tissue cooperatively modulate cellular fate, which results in naturally varying physiological functionality along distinct tissue regions [9,10]: hyaline cartilage composed of Yanen Wang and Ying Guo have contributed equally to this work. 1 3 water, collagen II, glycosaminoglycans (GAG), buffers the external forces and reduces friction during the motion of skeletal system; subchondral bone with the principal ECM constituents of collagen I and hydroxyapatite (HA) provides mechanical and structural support; calcified cartilage containing HA and collagen II plays a unique role in maintaining the structural continuity [11] and separating cartilage and subchondral bone [12].…”

Section: Introductionmentioning

confidence: 99%

Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds

et al. 2021

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Currently, osteochondral (OC) tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage. However, it is still challenging to ensure the integrity, physiological function and regeneration ability of stratified OC scaffolds in clinical application. Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue. As a consequence, the researches on biomimetic design to achieve the tissue function of each layer, and additive manufacture (AM) to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress. In this review, the design methods of biomaterial and structure as well as computer-aided design, and performance prediction of biopolymer-based OC scaffolds are presented; then, the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized; finally, the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.

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Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix

Cited by 8 publications

References 40 publications

Collagen‐Based Hydrogels for Cartilage Regeneration

Collagen‐Based Hydrogels for Cartilage Regeneration

Bioinspired gradient scaffolds for osteochondral tissue engineering

Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds

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